ArticleJournal of orthopaedic surgery and research2025
Bioelectronic osteosynthesis plate to monitor the fracture bone healing using electric capacitive variations.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Here today, gone tomorrow: the transformative role of biodegradable materials in modern trauma care.EFORT open reviews · 2026Pooled it
- From episodic imaging to real-time sensor monitoring: translational advances in assessing fracture healing dynamics.Journal of orthopaedic translation · 2026Review
- Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies.Biomechanics and modeling in mechanobiology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundBone fractures represent a global public health issue. Over the past few decades, a sustained increase in the number of incidents and prevalent cases have been reported, as well as in the years lived with disability. Current monitoring techniques predominantly rely on imaging methods, which can result in subjective assessments, and expose patients to unnecessary cumulative doses of radiation. Besides, they are costly and incapable of providing continuous daily detection of fracture healing stages. Technological advances are still required to design fixation systems with the ability to minimize the risk of delayed healing and nonunion conditions for timely medical intervention, such that preventive procedures can be provided. This work proposes.
methodsAn innovative bioelectronic osteosynthesis plate, minimally customized from a fixation device used in clinical practice, was developed to monitor the bone-implant interface to effectively detect the progression of bone fractures stages. Our technology includes a network-architectured capacitive interdigitated system, a Bluetooth module, an analog-to-digital converter, a multiplexer, a microcontroller, and a miniaturized battery.
resultsBoth experimental tests with biological tissues and numerical simulations show strong evidence that this bioelectronic implant is able: (i) to detect the four distinct bone healing stages, with capacitance decreases throughout the healing process; and (ii) to monitor the callus formation across multiple target regions.
conclusionsThis work provides a significant contribution to the design of bioelectronic implant technologies for highly personalized sensing of biointerfaces. Our bioelectronic fixation implant supports faster fracture healing, mainly for delayed healing and non-union conditions.
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Registered trials
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