Evidence map›Paper›PMID 39881343›Full record

ArticleBMC pharmacology & toxicology2025

λ-cyhalothrin induced sex-specific inflammation, glia activation and GABAergic interneuron disruption in the hippocampus of rats.

Aminu Imam, Christianah Oyegbola, Maryam Busari, Adewumi Mercy Gbemisola, Laaro Abubakar, Ajala Taofeeqoh Odunayo, Alhassan Godwin Attai, Ajibola Musa Iyiola, Wahab Abdulmajeed Imam, Aalimah Akinosho Akorede and 2 more

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Article in BMC pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aminu ImamDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria. imam.a@unilorin.edu.ng.
Christianah OyegbolaDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Maryam BusariDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Adewumi Mercy GbemisolaDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Laaro AbubakarDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Ajala Taofeeqoh OdunayoDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Alhassan Godwin AttaiDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Ajibola Musa IyiolaDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Wahab Abdulmajeed ImamDepartment of Physiology, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Aalimah Akinosho AkoredeDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Omamuyovwi Meashack IjomoneLaboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351103, Nigeria.
Moyosore Salihu AjaoDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlia mediated neuroinflammation and degeneration of inhibitory GABAergic interneurons are some of the hall marks of pyrethroid neurotoxicity. Here we investigated the sex specific responses of inflammatory cytokines, microglia, astrocyte and parvalbumin positive inhibitory GABAergic interneurons to λ-cyhalothrin (LCT) exposures in rats.

methodsEqual numbers of male and female rats were given oral corn oil, 2 mg/kg.bw and 4 mg/kg.bw of LCT for fourteen days. They were euthanized on day 15, brains were excised and hippocampus (n = 5/group) isolated for interleukin 1 beta (IL-1β) and tumor necrotic factor alpha (TNF-α) analysis. The remaining brains (n = 3/group) were processed for Ionized calcium binding adaptor molecule 1 (Iba1), glial fibrillary acidic protein (GFAP) and parvalbumin (PV) distribution in the hippocampus. All quantitative data was subjected to one way analysis of variance (ANOVA).

resultsLCT caused sex and dose dependent increase in IL-1β and TNF-α concentrations, distribution of microglia (Iba1+) and astrocytes (GFAP+), and reduction of PV + GABAergic interneurons. These effects were greater in males compared to females, and dose-dependent in both sexes.

conclusionLCT specifically induced inflammation and disrupted GABAergic interneurons' integrities via activation of microglia and reactive astrogliosis and such effects are dose-dependent and sexually dimorphic.

Indexed as

GABAergic NeuronsHippocampusInflammationInsecticidesInterneuronsNeurogliaNitrilesPyrethrinsAnimalsFemaleInterleukin-1betaMaleParvalbuminsRatsRats, Sprague-DawleySex CharacteristicscyhalothrinInsecticidesInterleukin-1betaNitrilesParvalbuminsPyrethrinsTumor Necrosis Factor-alphaGABAGliaHippocampusInflammationSexλ-cyhalothrin

Identifiers

PMID39881343
PMCPMC11780781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.