Observational studyJournal of neuroengineering and rehabilitation2025
Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study.
Observational study in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03522519 (Profiling and Predicting the Natural Course of Real World Physical Activity and Upper Limb Use After Stroke), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Profiling and Predicting the Natural Course of Real World Physical Activity and Upper Limb Use After Stroke
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of brain-computer interface-coupled robotic rehabilitation, robot-assisted therapy, and motor imagery for upper-limb motor recovery after stroke: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Advancing Neurorehabilitation and Recovery Through Human Movement Quantification via Wearable Sensing.Neurorehabilitation and neural repair · 2026Article
- From Metrics to Meaning in Neurological Rehabilitation: Clinicians' Perspectives on Digital Metrics of Upper Limb Functioning-A Focus Group Study.JMIR rehabilitation and assistive technologies · 2026Article
- White Matter Structural Biomarkers Derived from Diffusion Tensor Imaging to Estimate Upper-Extremity Motor Function in Stroke Using Machine Learning.Brain topography · 2026Article
- Standardized International Manual of the Fugl-Meyer Assessment of Motor Function After Stroke.Neurorehabilitation and neural repair · 2026Article
- Beyond the Wrist: Finger-Worn Accelerometers Enhance Assessment of Post-Stroke Motor Performance.Neurorehabilitation and neural repair · 2026Article
- Relationships between arm and leg real-life activity and clinical assessments in individuals with disabling spasticity after stroke.Frontiers in stroke · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConstruct validity and responsiveness of upper limb outcome measures are essential to interpret motor recovery poststroke. Evaluating the associations between clinical upper limb measures and sensor-based arm use (AU) fosters a coherent understanding of motor recovery. Defining sensor-based AU metrics for intentional upper limb movements could be crucial in mitigating bias from walking-related activities. Here, we investigate the measurement properties of a comprehensive set of clinical measures and sensor-based AU metrics when gait and non-functional upper limb movements are excluded.
methodsIn this prospective, longitudinal cohort study, individuals with motor impairment were measured at days 3 ± 2 (D3), 10 ± 2 (D10), 28 ± 4 (D28), 90 ± 7 (D90), and 365 ± 14 (D365) after their first stroke. Using clinical measures, upper limb motor function (Fugl-Meyer Assessment), capacity (Action Research Arm Test, Box & Block Test), and perceived performance (14-item Motor Activity Log) were assessed. Additionally, individuals wore five movement sensors (trunk, wrists, and ankles) for three days. Thirteen AU metrics were computed based on functional movements during non-walking periods. Construct validity across clinical measures and AU metrics was determined by Spearman's rank correlations for each time point. Criterion responsiveness was examined by correlating patient-reported Global Rating of Perceived Change (GRPC) scores and observed change in upper limb measures and AU metrics. Optimal cut-off values for minimal important change (MIC) were estimated by ROC curve analysis.
resultsNinety-three individuals participated. At D3 and D10, correlations between clinical measures and AU metrics showed variability (range r
conclusionsWe present reference data on the construct validity and responsiveness of clinical upper limb measures and specified sensor-based AU metrics within the first year after stroke. The MIC values can be used as a benchmark for clinical stroke rehabilitation.
trial registrationThis trial was registered on clinicaltrials.gov; registration number NCT03522519.
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