ArticleBMC medical imaging2025
Prediction of pulmonary function decline in fibrous interstitial lung abnormalities based on quantitative chest CT parameters.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Computed Tomography-Derived Bronchial Wall Indices in Cats with Clinical and Serological Features Compatible with Heartworm-Associated Respiratory Disease.Animals : an open access journal from MDPI · 2026Article
- Interstitial lung abnormalities: to treat or not to treat? The hamlet dilemma.Frontiers in medicine · 2026Review
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6 authors.
Funding
Abstract
backgroundInterstitial lung abnormalities (ILA) are a proposed imaging concept. Fibrous ILA have a higher risk of progression and death. Clinically, computed tomography (CT) examination is a frequently used and convenient method compared with pulmonary function tests. This study aimed to correlate quantitative CT airway parameters with pulmonary function parameters in patients with fibrous ILA, with the goal of establishing a prediction model for abnormal pulmonary function parameters in patients with fibrous ILA.
methodsNinety-five cases of fibrous ILA including CT images and 64 normal control cases were collected. All patients completed pulmonary function tests within one week. The airway parameters of the CT images of the two groups of cases were measured using a commercial software (Aview). Differences in airway parameters and lung function parameters between the two groups were analyzed by logistic multifactorial regression. The correlation between airway parameters and lung function parameters among 95 patients with fibrous ILA and a prediction model was determined for the decreased percentage forced vital capacity to predicted normal value (FVC%pred) in patients with fibrous ILA.
resultsLogistic multifactorial regression correlated FVC%pred and bronchial wall thickness (WT) were correlated with fibrous ILA. The 95 patients with fibrous ILA were divided into normal FVC%pred (n = 69) and decreased FVC%pred (n = 26) groups at the 80% cut-off. Logistic multifactorial regression revealed that FVC%pred decline in patients with fibrous ILA was effectively predicted by age (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.02-1.21, p = 0.014), gender (OR: 4.16,95% CI: 1.27-13.71, p = 0.019), luminal area of the sixth generation brochi (LA
conclusionWT is a quantitative CT biomarker and FVC%pred is a valid lung function parameter in fibrous ILA patients. Age, gender, LA CLINICAL TRIAL NUMBER: 2024K249.
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