ArticleJournal of exposure science & environmental epidemiology2025
Sub-micrometer scale synchrotron x-ray fluorescence measurements of trace elements in teeth compared with laser ablation inductively coupled plasma mass spectrometry.
Article in Journal of exposure science & environmental epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundElemental analysis of teeth allows for exposure assessment during critical windows of development and is increasingly used to link early life exposures and health. The measurement of inorganic elements in teeth is challenging; laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is the most widely used technique.
objectiveBoth synchrotron x-ray fluorescence (SXRF) and LA-ICP-MS have the capability to measure elemental distributions in teeth with each having distinct advantages and disadvantages.
methodsIn our study, we compared these two methods for teeth elemental quantification. SXRF was able to achieve spatial resolutions of 0.3 µm and is non-destructive while giving similar elemental quantification results to LA-ICP-MS.
resultsFor particular elements, SXRF can offer lower detection limits but depends on the specific beam intensity. The comparison between methods revealed less than 10% disagreement between quantification results from LA-ICP-MS and SXRF. IMPACT: Synchrotron x-ray fluorescence can be used to effectively quantify elemental distributions in teeth at a nanoscale resolution and is comparable to current laser ablation inductively coupled plasma mass spectrometry. Both methods offer advantages and disadvantages with LA-ICP-MS offering in-lab analyses, whereas SXRF offers much finer spatial and temporal scales and better detection capabilities. For studies focused on fine scale changes in structure, SXRF is more appropriate than LA-ICP-MS.
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