ArticleScientific reports2025
A volumetric study of the choroid plexus in neuropsychiatric systemic lupus erythematosus.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Immunopathogenesis of neuropsychiatric systemic lupus erythematosus: current insights into inflammatory and thrombotic pathways.Journal of neuroinflammation · 2026Review
- Alterations in the DTI-ALPS index and choroid plexus volume as brain-immune interfacing indicators in neuropsychiatric lupus erythematosus with inflammatory phenotype.Lupus science & medicine · 2026Article
- Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression.Frontiers in neuroscience · 2026Article
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9 authors.
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Abstract
Much evidence suggests that the choroid plexus (CP) plays an important role in the pathophysiology of systemic lupus erythematosus (SLE), but its imaging profile in neuropsychiatric SLE (NPSLE) remains unexplored. To evaluate CP volume in NPSLE patients using MRI. This retrospective study evaluated patients with SLE who underwent MRI of the brain, including three-dimensional T1-weighted imaging. CP volumes were automatically segmented. CP volume was evaluated using multivariable linear regression adjusted for age, sex, and total intracranial volume among three groups: NPSLE group, non-NPSLE group, and healthy control group (HC). Correlation analysis was performed between CP volume and clinical variables in the patient group. A total of 138 patients with SLE were included in the analysis. It was found that the right CP volume was greater in NPSLE compared with non-NPSLE and HC. When stratified according to their diagnosed status, newly diagnosed NPSLE had significantly greater CP volumes bilaterally compared with HC. Right CP volume was positively associated with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores in the patient group. All statistical significance levels were p < 0.05. CP enlargement could reflect a neuroinflammatory response that occurs at NPSLE disease onset. CP volume may serve as a promising marker for SLE, especially for newly diagnosed NPSLE.
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