Evidence map›Paper›PMID 39881134›Full record

ArticleNature communications2025

Intricacies of human-AI interaction in dynamic decision-making for precision oncology.

Dipesh Niraula, Kyle C Cuneo, Ivo D Dinov, Brian D Gonzalez, Jamalina B Jamaluddin, Jionghua Judy Jin, Yi Luo, Martha M Matuszak, Randall K Ten Haken, Alex K Bryant and 12 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Intelligent Reasoning Cues: A Framework and Case Study of the Roles of AI Information in Complex Decisions.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Unitary Entities Are the True "Atoms".Entropy (Basel, Switzerland) · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Dipesh NiraulaDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, USA. dipesh.niraula@moffitt.org.ORCID http://orcid.org/0000-0002-2245-8536
Kyle C CuneoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8264-6483
Ivo D DinovDepartment of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, USA.
Brian D GonzalezDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.
Jamalina B JamaluddinDepartment of Nuclear Engineering and Radiological Sciences, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6534-8388
Jionghua Judy JinDepartment of Industrial and Operations Engineering, University of Michigan, Ann Arbor, MI, USA.
Yi LuoDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-2519-5900
Martha M MatuszakDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Randall K Ten HakenDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Alex K BryantDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Thomas J DillingDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-0257-6989
Michael P DykstraDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Jessica M FrakesDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Casey L LiveringhouseDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Sean R MillerDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Matthew N MillsDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Russell F PalmDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-0448-8715
Samuel N ReganDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Anupam RishiDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Javier F Torres-RocaDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Hsiang-Hsuan Michael YuDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Issam El NaqaDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, USA. issam.elnaqa@moffitt.org.ORCID http://orcid.org/0000-0001-6023-1132

Funding

Optimal Decision Making in Radiotherapy Using Panomics AnalyticsR01CA233487 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2019 to 2023
$2.4M
NCI NIH HHS R01 CA233487U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA233487
6 · The paper itself

Abstract

AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics if clinicians over or under rely on AI. To investigate such collaborative decision-making process, we conducted a Human-AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. We investigated two levels of collaborative behavior: model-agnostic and model-specific; and found that Human-AI interaction is multifactorial and depends on the complex interrelationship between prior knowledge and preferences, patient's state, disease site, treatment modality, model transparency, and AI's learned behavior and biases. In summary, some clinicians may disregard AI recommendations due to skepticism; others will critically analyze AI recommendations on a case-by-case basis; clinicians will adjust their decisions if they find AI recommendations beneficial to patients; and clinician will disregard AI recommendations if deemed harmful or suboptimal and seek alternatives.

Indexed as

Artificial IntelligenceCarcinoma, HepatocellularCarcinoma, Non-Small-Cell LungClinical Decision-MakingDecision MakingLiver NeoplasmsLung NeoplasmsMedical OncologyPrecision MedicineDecision Support Systems, ClinicalFemaleHumansMale

Identifiers

PMID39881134
PMCPMC11779952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.