ArticleInsights into imaging2025
3D-AttenNet model can predict clinically significant prostate cancer in PI-RADS category 3 patients: a retrospective multicenter study.
Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- mpMRI-based clinic-radiomics-deep learning model integrating lesion and PPAT for predicting csPCa in PI-RADS category 3 lesions: a multicenter study.International urology and nephrology · 2026Article
- Deep learning for clinically significant prostate cancer detection on MRI: a systematic review, HSROC meta-analysis, and direct comparison with PI-RADS-based interpretation.Abdominal radiology (New York) · 2026Article
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13 authors.
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Abstract
purposesThe presence of clinically significant prostate cancer (csPCa) is equivocal for patients with prostate imaging reporting and data system (PI-RADS) category 3. We aim to develop deep learning models for re-stratify risks in PI-RADS category 3 patients.
methodsThis retrospective study included a bi-parametric MRI of 1567 consecutive male patients from six centers (Centers 1-6) between Jan 2015 and Dec 2020. Deep learning models with double channel attention modules based on MRI (AttenNet) for predicting PCa and csPCa were constructed separately. Each model was first pretrained using 1144 PI-RADS 1-2 and 4-5 images and then retrained using 238 PI-RADS 3 images from three training centers (centers 1-3), and tested using 185 PI-RADS 3 images from the other three testing centers (centers 4-6).
resultsOur AttenNet models achieved excellent prediction performances in testing cohort of center 4-6 with the area under the receiver operating characteristic curves (AUC) of 0.795 (95% CI: [0.700, 0.891]), 0.963 (95% CI: [0.915, 1]) and 0.922 (95% CI: [0.810, 1]) in predicting PCa, and the corresponding AUCs were 0.827 (95% CI: [0.703, 0.952]) and 0.926 (95% CI: [0.846, 1]) in predicting csPCa in testing cohort of center 4 and center 5. In particular, 71.1% to 92.2% of non-csPCa patients were identified by our model in three testing cohorts, who can spare from invasive biopsy or RP procedure.
conclusionsOur model offers a noninvasive screening clinical tool to re-stratify risks in PI-RADS 3 patients, thereby reducing unnecessary invasive biopsies and improving the effectiveness of biopsies. CRITICAL RELEVANCE STATEMENT: The deep learning model with MRI can help to screen out csPCa in PI-RADS category 3. KEY POINTS: AttenNet models included channel attention and soft attention modules. 71.1-92.2% of non-csPCa patients were identified by the AttenNet model. The AttenNet models can be a screen clinical tool to re-stratify risks in PI-RADS 3 patients.
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