Evidence map›Paper›PMID 39881005›Full record

ReviewNature reviews. Cancer2025

Cross-priming in cancer immunology and immunotherapy.

Carlos Luri-Rey, Álvaro Teijeira, Stefanie K Wculek, Carlos de Andrea, Claudia Herrero, Alvaro Lopez-Janeiro, María E Rodríguez-Ruiz, Ignacio Heras, Maria Aggelakopoulou, Pedro Berraondo and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Sequential Immune Activation of Effector T Cells as Biomarkers of Response to Durvalumab in Patients with Locally Advanced NSCLC.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Observational
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Discovery of MK-2118, a Small-Molecule Agonist of STING.ACS medicinal chemistry letters · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Bacterialized tumor cells as vaccine.EMBO molecular medicine · 2026
    Article
  18. Review
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlos Luri-ReyProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Álvaro TeijeiraProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Stefanie K WculekInnate Immune Biology Laboratory, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0001-5565-8561
Carlos de AndreaDepartment of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.
Claudia HerreroProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Alvaro Lopez-JaneiroDepartment of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.
María E Rodríguez-RuizDepartment of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
Ignacio HerasImmunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Maria AggelakopoulouNuffield Department of Medicine, University of Oxford, Oxford, UK.
Pedro BerraondoProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0001-7410-1865
David SanchoImmunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Ignacio MeleroProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain. imelero@unav.es.ORCID http://orcid.org/0000-0002-1360-348X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-presenting cells termed conventional type 1 dendritic cells (cDC1s) to cross-present antigens. Cross-presentation comprises redirection of exogenous antigens taken from other cells to the major histocompatibility complex class I antigen-presenting machinery. In addition, once activated and having sensed viral moieties or T helper cell cooperation via CD40-CD40L interactions, cDC1s provide key co-stimulatory ligands and cytokines to mount and sustain CD8

Indexed as

Cross-PrimingImmunotherapyNeoplasmsAnimalsCD8-Positive T-LymphocytesDendritic CellsHumansMiceTumor Microenvironment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.