Evidence map›Paper›PMID 39881001›Full record

ArticleNature immunology2025

Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation.

Daniel Inácio, Tiago Amado, Ana Pamplona, Daniel Sobral, Carolina Cunha, Rita F Santos, Liliana Oliveira, Nelly Rouquié, Alexandre M Carmo, Renaud Lesourne and 2 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  10. HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel InácioGulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Tiago Amado *Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Ana Pamplona *Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Daniel SobralInstituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal.
Carolina CunhaGulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Rita F SantosInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Liliana OliveiraInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Nelly RouquiéToulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse, France.ORCID http://orcid.org/0000-0002-2347-9160
Alexandre M CarmoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0002-2508-9799
Renaud LesourneToulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse, France.ORCID http://orcid.org/0000-0003-3816-7087
Anita Q GomesGulbenkian Institute for Molecular Medicine, Lisbon, Portugal. anita.gomes@gimm.pt.ORCID http://orcid.org/0000-0002-3348-0448
Bruno Silva-SantosGulbenkian Institute for Molecular Medicine, Lisbon, Portugal. bssantos@medicina.ulisboa.pt.ORCID http://orcid.org/0000-0003-4141-9302

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 646701
6 · The paper itself

Abstract

γδ T cells producing either interleukin-17A (γδ

Indexed as

CytokinesLymphocyte ActivationMalaria, CerebralReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTranscriptomeAnimalsEncephalomyelitis, Autoimmune, ExperimentalGene Expression ProfilingInterferon-gammaInterleukin-17MiceMice, Inbred C57BLMice, TransgenicCytokinesInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID39881001
PMCPMC11876068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.