Evidence map›Paper›PMID 39880949›Full record

ArticleNature2025

Engineered heart muscle allografts for heart repair in primates and humans.

Ahmad-Fawad Jebran, Tim Seidler, Malte Tiburcy, Maria Daskalaki, Ingo Kutschka, Buntaro Fujita, Stephan Ensminger, Felix Bremmer, Amir Moussavi, Huaxiao Yang and 45 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Organoid-based strategies and challenges in tissue regeneration].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Super-Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  18. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Ahmad-Fawad Jebran *Department of Cardiothoracic and Vascular Surgery, University Medical Center Göttingen, Göttingen, Germany.
Tim Seidler *German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0002-6158-5087
Malte Tiburcy *German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0002-6942-6275
Maria DaskalakiGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Ingo KutschkaDepartment of Cardiothoracic and Vascular Surgery, University Medical Center Göttingen, Göttingen, Germany.
Buntaro FujitaClinic for Cardiac and Thoracic Vascular Surgery, University Medical Center Schleswig Holstein, Campus Lübeck, Lübeck, Germany.
Stephan EnsmingerClinic for Cardiac and Thoracic Vascular Surgery, University Medical Center Schleswig Holstein, Campus Lübeck, Lübeck, Germany.
Felix BremmerGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Amir MoussaviGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Huaxiao YangStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Xulei QinStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Sophie MißbachGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Charis DrummerGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Hassina BarakiDepartment of Cardiothoracic and Vascular Surgery, University Medical Center Göttingen, Göttingen, Germany.
Susann BoretiusGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0003-2792-7423
Christopher HasenauerInstitute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany.
Tobias NetteInstitute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany.
Johannes KowallickGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Christian O RitterGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Joachim LotzGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Michael DidiéGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Mathias MietschGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Tim MeyerGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0002-0521-6711
George KensahDepartment of Cardiothoracic and Vascular Surgery, University Medical Center Göttingen, Göttingen, Germany.
Dennis KrügerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.ORCID 0000-0003-1950-9547
Md Sadman SakibDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Lalit KauraniDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Andre FischerGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Ralf DresselGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Ignacio Rodriguez-PoloGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0003-1254-4972
Michael StauskeGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Sebastian DieckePluripotent Stem Cells Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-5219-5992
Kerstin Maetz-RensingPathology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Eva Gruber-DujardinPathology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Martina BleyerPathology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Beatrix PetersenGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Christian RoosPrimate Genetics Laboratory, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.ORCID 0000-0003-0190-4266
Liye ZhangPrimate Genetics Laboratory, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.ORCID 0000-0002-8829-0588
Lutz WalterGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Silke KaulfußInstitute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Gökhan YigitGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0003-2777-0198
Bernd WollnikGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0003-2589-0364
Elif LeventGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Berit RoshaniUnit of Infection Models, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Christiane Stahl-HenningUnit of Infection Models, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Philipp StröbelInstitute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Tobias LeglerGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0002-1408-5397
Joachim RiggertGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Kristian HellenkampDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
Jens-Uwe VoigtDepartment of Cardiovascular Sciences, Catholic University of Leuven and Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-0575-1888
Gerd HasenfußGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Rabea HinkelGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6068-8041
Rüdiger BehrGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.ORCID 0000-0001-8816-6619
Wolfram-Hubertus ZimmermannGerman Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany. w.zimmermann@med.uni-goettingen.de.ORCID 0000-0003-1190-4040

Funding

California Institute of Regenerative MedicineGerman Federal Ministry of Science and EducationGerman Research FoundationLeducq Foundation
6 · The paper itself

Abstract

Cardiomyocytes can be implanted to remuscularize the failing heart

Indexed as

AllograftsHeart FailureMyocardiumTissue EngineeringAnimalsDisease Models, AnimalFemaleHumansInduced Pluripotent Stem CellsMacaca mulattaMaleMyocardial InfarctionMyocytes, CardiacRatsRats, NudeTransplantation, Homologous

Identifiers

PMID39880949
PMCPMC11903342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.