Evidence map›Paper›PMID 39880944›Full record

ArticleNature2025

Copper-dependent halogenase catalyses unactivated C-H bond functionalization.

Chen-Yu Chiang, Masao Ohashi, Jessie Le, Pan-Pan Chen, Qingyang Zhou, Songrong Qu, Undramaa Bat-Erdene, Shabnam Hematian, Jose A Rodriguez, K N Houk and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Emerging classes of copper enzymes.Current opinion in chemical biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen-Yu ChiangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Masao OhashiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. gph422001@ucla.edu.ORCID 0000-0001-7103-541X
Jessie LeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Pan-Pan ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3209-3841
Qingyang ZhouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Songrong QuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1179-6468
Undramaa Bat-ErdeneDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Shabnam HematianDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID 0000-0002-0788-7615
Jose A RodriguezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
K N HoukDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8387-5261
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-4132-3565
Joseph A LooDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9989-1437
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu.ORCID 0000-0003-1597-0141

Funding

MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
Biosynthesis and Enzymology of Antifungal Natural Products - R01AI141481R01AI141481 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K, HOUK, KENDALL N · 2019 to 2023
$2.8M
Advancing Mass Spectrometry Analyses of Proteins, Assemblies, and ProteoformsR35GM145286 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A Loo · 2022 to 2026
$1.9M
Multinuclear Dioxygen-Utilizing Copper Enzymes: Diverse Roles for Aromatic Redox Active Amino AcidsR35GM150762 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Shabnam Hematian · 2023 to 2026
$1.5M
NIAID NIH HHS R01 AI141481NIGMS NIH HHS R35 GM118056NIGMS NIH HHS R35 GM145286NIGMS NIH HHS R35 GM150762
6 · The paper itself

Abstract

Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp

Indexed as

BiocatalysisCarbonCopperHydrogenOxidoreductasesCatalytic DomainHalogenationModels, MolecularCarbonCopperHydrogenOxidoreductases

Identifiers

PMID39880944
PMCPMC12145154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.