ArticleNPJ precision oncology2025
The burden and temporal trend of early onset pancreatic cancer based on the GBD 2021.
Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Disease Burden of Early-Onset Pancreatic Cancer in Adults Aged 20-54 Years in Low- and Middle-Income Countries: A GBD 2023 Analysis.Digestive diseases and sciences · 2026Article
- Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats.Aging cell · 2026Article
- Persistent Global Associations Between Gallbladder-Biliary Diseases and Pancreatic Cancer: Evidence from 204 Countries and Territories Over 32 years.Digestive diseases and sciences · 2026Article
- Development and validation of a nomogram for predicting distant metastasis and prognosis in elderly T1-T2 pancreatic ductal adenocarcinoma patients.Discover oncology · 2026Article
- Clinical Application Progress of Artificial Intelligence in Pancreatic Cancer: From Diagnosis to Immunotherapy.Oncology research · 2026Review
- Lifetime Probability of Developing Migraine: A Novel Epidemiological Perspective Based on Global Burden of Disease Data.Pain research & management · 2026Article
- Growing burden of early-onset pancreatic cancer without increasing risk: what is the trick.NPJ precision oncology · 2025Article
- Article
- Burden of pancreatic cancer among the Western Pacific Region and association with human resources for health from 1990 to 2021: Results from the Global Burden of Disease Study 2021.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Divergent trajectories in pancreatic cancer burden among older adults (55+): a GBD 2021 analysis revealing China's dual epidemic of aging and population growth (1990-2045).Frontiers in public health · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
In the context of the global increase in early-onset tumours, investigating the global disease burden caused by early-onset pancreatic cancer (EOPC) is imperative. Data on the burden of EOPC were obtained from the Global Burden of Disease Study 2021. A joinpoint regression model was used to analyse the temporal trend of the EOPC burden, and an age‒period‒cohort (APC) model was used to analyse the influence of age, period, and birth cohort on burden trends. Globally, the number of EOPC cases increased from 24,480 to 42,254, and the number of deaths increased from 17,193 to 26,996 between 1990 and 2021. The results of the APC model showed that the burden of EOPC increases with increasing age, whereas the variations in period and cohort effects exhibited a complex pattern across different sociodemographic index regions. Consequently, the disease burden of EOPC is increasing worldwide, highlighting the need for effective interventions.
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