Evidence map›Paper›PMID 39880793›Full record

ArticleInfection control and hospital epidemiology2025

Prospective, crossover, comparative study of two methods of chlorhexidine bathing.

Richard Jordan Hankins, Luke Handke, Paul D Fey, Ruth Jennifer Cavalieri, Kelly A Cawcutt, Trevor Van Schooneveld, Elizabeth Lyden, Robin High, Mark E Rupp

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection control and hospital epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Richard Jordan HankinsDivision of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-8763-3374
Luke HandkePathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Paul D FeyPathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Ruth Jennifer CavalieriDivision of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-8791-9719
Kelly A CawcuttDivision of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-3586-0951
Trevor Van SchooneveldDivision of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-9928-4546
Elizabeth LydenEpidemiology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-1635-6365
Robin HighEpidemiology, University of Nebraska Medical Center, Omaha, NE, USA.
Mark E RuppDivision of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-8946-8272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBathing intensive care unit (ICU) patients with chlorhexidine gluconate (CHG) decreases healthcare-associated infections (HAIs). The optimal method of CHG bathing remains undefined.

methodsProspective crossover study comparing CHG daily bathing with 2% CHG-impregnated cloths versus 4% CHG solution. In phase 1, from January 2020 through March 2020, 1 ICU utilized 2% cloths, while the other ICU utilized 4% solution. After an interruption caused by the coronavirus disease 2019 pandemic, in phase 2, from July 2020 through September 2020, the unit CHG bathing assignments were reversed. Swabs were performed 3 times weekly from patients' arms and legs to measure skin microbial colonization and CHG concentration. Other outcomes included HAIs, adverse reactions, and skin tolerability.

results411 assessments occurred after baths with 2% cloth, and 425 assessments occurred after baths with 4% solution. Average microbial colonization was 691 (interquartile range 0, 30) colony-forming units per square centimeter (CFU/cm

conclusionsEither CHG bathing method resulted in a significant decrease in microbial skin colonization with a greater CHG concentration and fewer organisms associated with 2% CHG cloths.

Indexed as

Anti-Infective Agents, LocalBathsChlorhexidineCross InfectionAdultAgedCOVID-19Cross-Over StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesSkinAnti-Infective Agents, LocalChlorhexidinechlorhexidine gluconate

Identifiers

PMID39880793
PMCPMC11883645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.