ReviewThe Veterinary clinics of North America. Equine practice2025
Myosin Heavy Chain Myopathy and Immune-Mediated Muscle Disorders.
Review in The Veterinary clinics of North America. Equine practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Several inflammatory myopathies have an infectious or immune-mediated basis in the horse. Myosin heavy chain myopathy is caused by a codominant missense variant in MYH1 and has 3 clinical presentations: immune-mediated myositis, calciphylaxis, and nonexertional rhabdomyolysis in Quarter Horse-related breeds. An infarctive form of purpura hemorrhagica affects numerous breeds, presenting with focal firm, painful muscle swelling, and subsequent infarction of multiple tissues. While Streptococcus equi equi is often the inciting cause, anaplasmosis, sarcocystis, piroplasmosis, viruses, and vaccines can also be inciting agents. This article describes the diagnosis, pathophysiology, and treatment of these inflammatory myopathies.
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