Evidence map›Paper›PMID 39880690›Full record

SynthesisAJNR. American journal of neuroradiology2025

Posterior Fossa Ring-Enhancing Lesions in the Adult Immunocompetent Host: Illustrative Cases, Systematic Review, and Proposed Diagnostic Algorithm.

Elisabeth Van Boxstael, Alexia de Hennin, Eric Vigneul, Pasquale Scoppettuolo, Souraya El Sankari, Anna Paola Bocchio, Serena Borrelli, Valentina Lolli, Vincent van Pesch, Sofia Maldonado Slootjes and 4 more

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elisabeth Van BoxstaelFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Alexia de HenninFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Eric VigneulDepartment of Neurosurgery (E.V., P.F.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Pasquale ScoppettuoloFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Souraya El SankariFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Anna Paola BocchioDepartment of Radiology (A.P.B.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Serena BorrelliDepartment of Neurology (S.B.), Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Valentina LolliDepartment of Radiology (V.L.), Hôpital Erasme, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium.ORCID https://orcid.org/0000-0002-5555-1745
Vincent van PeschFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0000-0003-2885-9004
Sofia Maldonado SlootjesDepartment of Neurology (S.M.S.), UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Patrice FinetDepartment of Neurosurgery (E.V., P.F.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Àlex RoviraSection of Neuroradiology (A.R.), University Hospital Vall d'Hebron, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2132-6750
Daniel S ReichTranslational Neuroradiology Section (D.S.R.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.ORCID https://orcid.org/0000-0002-2628-4334
Pietro MaggiFrom the Department of Neurology (E.V.B., A.d.H., P.S., S.E.S, V.v.P., P.M.), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium pietro.maggi@uclouvain.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posterior fossa ring-enhancing lesions (PFREL) in immunocompetent adults represent a diagnostic challenge. We conducted a retrospective institutional analysis combined with a systematic literature review (PRISMA 2020) to describe the etiological spectrum of PFREL and to develop a diagnostic algorithm. Among 116 cases reviewed, infectious causes were most common (52%), followed by tumoral (38%) and inflammatory (2%) etiologies. Headache was the most frequent symptom, and 36% of patients presented with multiple lesions. Reported outcomes varied, with complete symptom resolution in 36% of cases and a mortality rate of 16%. Based on clinical and radiological features, we proposed a diagnostic algorithm, which was validated on an independent cohort of 16 patients and provided correct classification in each case. This algorithm may support the diagnostic process in PFREL and help to guide further investigations and management.

Indexed as

AlgorithmsCranial Fossa, PosteriorImmunocompetenceInfratentorial NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID39880690
PMCPMC12453516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.