Evidence map›Paper›PMID 39880687›Full record

ArticleAJNR. American journal of neuroradiology2025

Effects of Psilocybin on Mouse Brain Microstructure.

Paloma C Frautschi, Ajay P Singh, Nicholas A Stowe, Sean M Grady, Zarmeen Zahid, Matthew I Banks, John-Paul J Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paloma C FrautschiFrom the Department of Radiology (P.C.F., A.P.S., J.-P.J.Y.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ajay P SinghFrom the Department of Radiology (P.C.F., A.P.S., J.-P.J.Y.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Nicholas A StoweNeuroscience Training Program, Wisconsin Institutes for Medical Research (N.A.S., Z.Z., M.I.B., J.-P.J.Y.), University of Wisconsin-Madison, Madison, Wisconsin.
Sean M GradyDepartment of Anesthesiology (S.M.G. M.I.B.), School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0009-0009-8013-858X
Zarmeen ZahidNeuroscience Training Program, Wisconsin Institutes for Medical Research (N.A.S., Z.Z., M.I.B., J.-P.J.Y.), University of Wisconsin-Madison, Madison, Wisconsin.
Matthew I BanksNeuroscience Training Program, Wisconsin Institutes for Medical Research (N.A.S., Z.Z., M.I.B., J.-P.J.Y.), University of Wisconsin-Madison, Madison, Wisconsin.
John-Paul J YuFrom the Department of Radiology (P.C.F., A.P.S., J.-P.J.Y.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin jp.yu@wisc.edu.

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

background and purposeThere is surging interest in the therapeutic potential of psychedelic compounds like psilocybin in the treatment of psychiatric illnesses like major depressive disorder (MDD). Recent studies point to the rapid antidepressant effect of psilocybin; however, the biologic mechanisms underlying these differences remain unknown. This study determines the feasibility of using diffusion MRI to characterize and define the potential spatiotemporal microstructural differences in the brain following psilocybin treatment in C57BL/6J male mice. MATERIALS AND

methodsEleven- to 15-week-old C57BL/6J male mice were randomly assigned to receive psilocybin, 6-fluoro-N, N-diethyltryptamine, or saline and ex vivo imaged 24 hours (

resultsPsilocybin-treated mice demonstrated structural connectivity differences at 72 hours in the frontal association cortex (compared with saline, mean tract length increases,

conclusionsDiffusion microstructure imaging and white matter tractography are sensitive methods to detect and characterize the neural substrates and microstructural differences accompanying psilocybin treatment. These findings suggest the potential role for diffusion microstructure imaging to quantify the bioeffects of psychedelics like psilocybin on the brain, monitor treatment response, and identify salient clinical end points in an emerging therapeutic option for patients with MDD.

Indexed as

BrainHallucinogensPsilocybinAnimalsDiffusion Tensor ImagingMaleMiceMice, Inbred C57BLHallucinogensPsilocybin

Identifiers

PMID39880687
PMCPMC12152794

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.