Evidence map›Paper›PMID 39880680›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors.

Ernest C Y Ho 何鎮宇, Adam J H Newton, Eugenio Urdapilleta, Salvador Dura-Bernal, Wilson Truccolo

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ernest C Y Ho 何鎮宇Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Adam J H NewtonDepartment of Physiology and Pharmacology, State University of New York (SUNY), Downstate Health Sciences University, Brooklyn, New York 11203.
Eugenio UrdapilletaCentro Atómico Bariloche and Instituto Balseiro, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, R8402AGP Bariloche, Río Negro, Argentina.
Salvador Dura-BernalDepartment of Physiology and Pharmacology, State University of New York (SUNY), Downstate Health Sciences University, Brooklyn, New York 11203.
Wilson TruccoloDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912 wilson_truccolo@brown.edu.

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Michael Peter Milham · 2017 to 2026
$25.3M
Multi-Scale Cortical Dynamics in Human EpilepsyR01NS079533 · NINDS · BROWN UNIVERSITY · PI TRUCCOLO, WILSON · 2012 to 2022
$3.4M
Dissemination of a tool for data-driven multiscale modeling of brain circuitsU24EB028998 · NIBIB · SUNY DOWNSTATE MEDICAL CENTER · PI DURA-BERNAL, SALVADOR · 2019 to 2023
$1.6M
Brain Science Compute ClusterS10OD025181 · OD · BROWN UNIVERSITY · PI SANES, JEROME N · 2019 to 2019
$600k
Modern On-Site High Performance Computing SystemS10OD032417 · OD · SUNY DOWNSTATE MEDICAL CENTER · PI BUNNELL, SCOTT · 2022 to 2022
$578k
NIBIB NIH HHS U24 EB028998NIH HHS S10 OD025181NIH HHS S10 OD032417NIMH NIH HHS P50 MH109429NINDS NIH HHS R01 NS079533
6 · The paper itself

Abstract

Voltage-gated potassium conductances

Indexed as

Cerebral CortexDown-RegulationEpilepsyModels, NeurologicalNerve NetPotassium4-AminopyridineAction PotentialsAnimalsHumansNeurons4-AminopyridinePotassium4-aminopyridinefocal epilepsyionic diffusionnetwork synchronization

Identifiers

PMID39880680
PMCPMC11949479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.