Evidence map›Paper›PMID 39880473›Full record

ArticleBMJ case reports2025

Persistent low concentrations of antiepileptics in a critically ill paediatric patient: an example of multiple potential drug interactions.

Lone Bak Posada, Anne Estrup Olesen, Tine Høg Sørensen, Samuel Azuz

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lone Bak PosadaClinical Pharmacology, Aalborg University Hospital, Aalborg, Region Nordjylland, Denmark.
Anne Estrup OlesenClinical Pharmacology, Aalborg University Hospital, Aalborg, Region Nordjylland, Denmark.ORCID http://orcid.org/0000-0001-9365-1918
Tine Høg SørensenPaediatrics, Aalborg University Hospital, Aalborg, Denmark.
Samuel AzuzClinical Pharmacology, Aalborg University Hospital, Aalborg, Region Nordjylland, Denmark s.azuz@rn.dk.ORCID http://orcid.org/0000-0003-4294-0124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A middle childhood boy with epilepsy exhibited persistent low concentrations of valproic acid, lamotrigine and topiramate for over 1 month, primarily due to pharmacokinetic interactions involving fosphenytoin, meropenem and phenobarbital. Awareness of these clinically significant interactions is crucial for ensuring effective seizure control. However, further research is needed to establish optimal evidence-based treatment strategies in complex paediatric cases.

Indexed as

AnticonvulsantsEpilepsyChildCritical IllnessDrug InteractionsFructoseHumansLamotrigineMaleMeropenemPhenobarbitalPhenytoinTopiramateTriazinesValproic AcidAnticonvulsantsfosphenytoinFructoseLamotrigineMeropenemPhenobarbitalPhenytoinTopiramateTriazinesValproic AcidDrug interactionsEpilepsy and seizuresPaediatrics (drugs and medicines)Pharmacokinetics

Identifiers

PMID39880473
PMCPMC11780581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.