ArticleThe Journal of allergy and clinical immunology2025
Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report-a GA
Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypersensitivity reactions to contrast media: Part 1. Management of immediate and non-immediate hypersensitivity reactions in adults. Updated guidelines by the ESUR Contrast Media Safety Committee.European radiology · 2025Guideline
- Telemedicine-guided management of iodinated contrast media-associated anaphylaxis: A case report.Radiology case reports · 2026Article
- Under the Drapes: Unmasking the Mechanisms and Clinical Diagnosis of Perioperative Hypersensitivity.Current allergy and asthma reports · 2026Review
- Age-related differences in pediatric anaphylaxis: a single-center experience.BMC pediatrics · 2026Observational
- Epidemiological shifts and temporal trends in emergency department anaphylaxis management: An 18-year longitudinal study in northern Thailand.The World Allergy Organization journal · 2026Article
- Type I Interferon Signature is Associated With Lung Disease, Drug-Associated Immune Reactions, and Genetic Variation in Interferon-Linked Pathways in Still Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Nationwide epidemiology and healthcare burden of pediatric anaphylaxis in Thailand: A population-based study, 2019-2023.The World Allergy Organization journal · 2026Article
- [How I treat anaphylaxis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Epinephrine Underuse for Anaphylaxis in Infants and Toddlers: A Practical Review for Pediatricians.Paediatric drugs · 2026Review
- Article
- Novelties in the pragmatic management of anaphylaxis in pediatric age.European journal of pediatrics · 2026Review
- Real-life lessons on omalizumab and food allergy: The potential for unexplored outcomes.The World Allergy Organization journal · 2026Review
- Anaphylaxis: Clinical Criteria, Severity, and Clinical Courses.Immunology and allergy clinics of North America · 2026Review
- Negative-Pressure Pulmonary Hemorrhage: A Case Report and Review of Differential Diagnosis.Cureus · 2026Article
- Overview of allergic disease: Anaphylaxis - WAO White Book on Allergy 2026 - 2.11.The World Allergy Organization journal · 2026Review
- Italian Evidence-Based Clinical Recommendations on the Appropriateness of Prescriptions and Diagnostic Tests in Pediatric Allergology: Focus on Anaphylaxis, Drug Allergy and Hymenoptera Venom Allergy.Journal of clinical medicine · 2026Review
- Neutrophil extracellular trap-associated responses are associated with tissue factor expression and coagulation abnormalities during anaphylaxis.Frontiers in immunology · 2026Article
- Management of paediatric anaphylaxis: evaluation of clinical practice according to the 2024 Polish Paediatric Society guidelines.Postepy dermatologii i alergologii · 2026Article
- Sudden suspected anaphylactic shock after multiple tolerated doses of piperacillin-tazobactam: a case report and literature review.Frontiers in medicine · 2026Article
- Food-induced anaphylaxis following skin prick testing: a case report and literature review.Frontiers in allergy · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe 2006 National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network anaphylaxis criteria are widely used in clinical care and research. In 2020, the World Allergy Organization published modified criteria that have not been uniformly adopted. Different criteria contribute to inconsistent care and research outcomes.
objectiveWe sought to develop a consensus anaphylaxis definition, overview, and clinical support tool.
methodsA 12-member writing group developed draft outputs modified with input from a 46-member international expert panel, 31 medical stakeholder organizations, and 15 patient advocacy organizations. The expert panel participated in a modified Delphi process to seek consensus for the outputs using a ≥80% consensus threshold.
resultsThe first sentence of the definition reads, "Anaphylaxis is a serious allergic (hypersensitivity) reaction that can progress rapidly and may cause death." The definition also describes organ systems that may be involved and signs of life-threatening reactions. The overview includes details of anaphylaxis recognition and management. The clinical support tool incorporates new clinical criteria to help determine the likelihood that patients are having anaphylaxis, intramuscular epinephrine indications and dosing, and common findings from the anaphylaxis organ systems. In addition, 93.5% (43/46), 97.8% (45/46), and 93.5% (43/46) of experts agreed with the definition, overview, and clinical support tool, respectively.
conclusionThe anaphylaxis overview is a novel educational tool conveying key elements of anaphylaxis recognition and management. We propose that the definition and clinical support tool should replace previous definitions and clinical criteria. The clinical support tool should facilitate improved anaphylaxis recognition and management across different clinical settings and standardize research outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.