Trial reportChest2025
Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life.
Trial report in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03671447 (Enhanced Recovery After Intensive Care), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhanced Recovery After Intensive Care (ERIC) - a Multi-Center Stepped Wedge Cluster-Randomized Controlled Trial
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nursing in critical care · 2026Pooled it
- The impact of an intensive care telemedicine program on weaning from invasive ventilation: a secondary analysis of the ERIC trial.Critical care (London, England) · 2026Trial
- Effectiveness of a standardized weaning protocol in tracheostomized patients with prolonged mechanical ventilation: a prospective single-arm interventional trial.Journal of intensive care · 2026Article
- The LoVe score: Development and validation of a bedside clinical index to identify patients at risk for prolonged invasive mechanical ventilation.Journal of the Intensive Care Society · 2026Article
- Minimum observation time to determine ventilator liberation success and its associated factors in tracheostomized patients in intensive and high-care units in Japan: a single-center retrospective study.Acute and critical care · 2026Article
- Respiratory Rehabilitation and Decannulation in Adults with Prolonged Mechanical Ventilation After Tracheostomy: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Surrogate Perspectives on the Communication and Support Processes That Enable Them as Active Decision-Makers Across Chronic Critical Illness.CHEST critical care · 2026Article
- Clinical Predictors of Weaning Failure and Mortality in Individuals With COVID-19 Undergoing Invasive Mechanical Ventilation: A Retrospective Cohort Study.Pulmonary medicine · 2026Article
- Bronchoscopy-guided non-capping decannulation pathway versus conventional capping trial in patients with prolonged tracheostomy: a retrospective comparative cohort study.Frontiers in medicine · 2026Article
- Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited knowledge about long-term mortality, care pathways, and health-related quality of life (HrQoL) among patients in the ICU receiving prolonged mechanical ventilation (PMV). RESEARCH QUESTION: What are the long-term mortality, care pathways, and HrQoL of patients receiving invasive PMV, stratified by weaning success? STUDY DESIGN AND
methodsWe conducted a secondary analysis of patients from the cluster-randomized controlled Enhanced Recovery After Intensive Care trial who were treated in 2 ICU clusters and received invasive PMV (≥ 21 days via endotracheal tube/tracheostomy or ≥ 4 days via tracheostomy). Data on weaning success, mortality, care place transitions, readmissions, and HrQoL were collected for 6 months after ICU discharge.
resultsOf 90 patients receiving PMV in the ICU, 46% (41 of 90 patients) died (21 patients in the ICU and 20 patients within 6 months after ICU discharge). Of 69 patients discharged alive, 25% (17 of 69 patients) could not be weaned, whereas 75% (52 of 69 patients) were successfully weaned within 6 months. Patients experienced a median of 3 (Q1, Q3: 2, 5) care place transitions within 6 months, with more care place transitions among successfully weaned patients (median, 4 [Q1, Q3: 2, 5] vs 2 [1, 3], P = .004). The readmission rate among all patients was 46% within 6 months. One-half of the successfully weaned patients transitioned home, whereas unsuccessfully weaned patients mostly transitioned from weaning centers to nursing homes or died. Unsuccessfully weaned patients had fewer quality-adjusted life days within 6 months than successfully weaned patients (median, 0 [Q1, Q3: 0, 32.6] vs 73.1 [23.2, 135], P = .002).
interpretationOur results show that three-quarters of patients receiving PMV who were discharged alive were weaned, but their HrQoL was reduced. The decision to proceed with PMV should weigh in patient preferences for living with HrQoL limitations and patients' likelihood of weaning. CLINICAL
trial registrationClinicalTrials.gov; No.: NCT03671447; URL: www. CLINICALTRIALS: gov.
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