ArticleNature2025
Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
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Who cites it
10 citing papers in PubMed.
- γ-glutamyl carboxylase inhibition by Anisindione.Structure (London, England : 1993) · 2026Article
- Giant viruses encode vitamin K-based redox modules for lipid modification.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy.Blood advances · 2026Article
- Structural basis for the carboxylation and epoxidation of human gamma-glutamyl carboxylase.Nature communications · 2026Article
- Structural and functional insights into γ-glutamyl carboxylase-factor IX interaction: implications for vitamin K-dependent bleeding disorders.Haematologica · 2026Article
- Molecular insights into the comorbidity of vitamin K-dependent clotting factor deficiency and chondrodysplasia punctata.Journal of thrombosis and haemostasis : JTH · 2025Article
- Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase.Nature communications · 2025Article
- Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation.Cell research · 2025Article
- Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.Cell research · 2025Article
- Osteocalcin has many tricks to get γ-carboxylated.Cell research · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Qing CaoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-2517-2231
Aaron AmmermanDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-9245-4015
Mierxiati SaimiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Zongtao LinDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Guomin ShenDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-5006-2790
Huaping ChenDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-9835-5138
Jie SunDepartment of Chemistry, Washington University, St Louis, MO, USA.ORCID 0000-0001-8775-5032
Mengqi ChaiDepartment of Chemistry, Washington University, St Louis, MO, USA.
Shixuan LiuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Fong-Fu HsuDepartment of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Andrzej M KrezelDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Michael L GrossDepartment of Chemistry, Washington University, St Louis, MO, USA.ORCID 0000-0003-1159-4636
Jinbin XuDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-2120-8287
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3596-4750
Bin LiuThe Hormel Institute, University of Minnesota, Austin, MN, USA. liu00794@umn.edu.ORCID 0000-0002-6581-780X
Weikai LiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA. weikai@wustl.edu.ORCID 0000-0002-8711-1904
Funding
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 2020 to 2026
$28.7MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MSTRUCTURAL AND FUNCTIONAL BASIS OF THE VITAMIN K CYCLER01HL121718 · NHLBI · WASHINGTON UNIVERSITY · PI Weikai Li · 2014 to 2026
$5.2MNEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLSR01GM131008 · NIGMS · WASHINGTON UNIVERSITY · PI MICHAEL L GROSS, Weikai Li · 2019 to 2026
$3.8MDissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6MDefining the partner interaction network of the tetraspanin CD53 in regulating B cell traffickingR01AI158500 · NIAID · WASHINGTON UNIVERSITY · PI Weikai Li, LAURA G. SCHUETTPELZ · 2022 to 2026
$2.8MQuantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6MA Mass Spectrometry Approach to the Genetic and Epigenetic Mechanisms Controlling Neuronal IdentityR01NS111997 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAHMANE, NADIA, GARCIA, BENJAMIN A · 2020 to 2024
$2.6MPOSTMORTEM VALIDATION OF BIOMARKERS FOR IMAGING PARKINSON DISEASER01NS092865 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN · 2016 to 2020
$1.7MStructural and Biochemical Basis of the Vitamin K cycleR00HL097083 · NHLBI · WASHINGTON UNIVERSITY · PI LI, WEIKAI · 2011 to 2013
$735kStructural and Biochemical Basis of the Vitamin K cycleK99HL097083 · NHLBI · HARVARD MEDICAL SCHOOL · PI LI, WEIKAI · 2009 to 2010
$180kNHLBI NIH HHS K99 HL097083NHLBI NIH HHS R00 HL097083NHLBI NIH HHS R01 HL121718NIAID NIH HHS R01 AI158500NIA NIH HHS P30 AG066444NICHD NIH HHS R01 HD106051NIDDK NIH HHS P30 DK020579NIGMS NIH HHS R01 GM131008NINDS NIH HHS R01 NS092865NINDS NIH HHS R01 NS111997NINDS NIH HHS R01 NS123571
Abstract
The γ-carboxylation of glutamate residues enables Ca
Indexed as
Cell MembraneVitamin KCryoelectron MicroscopyGlutamic AcidHumansHydroquinonesModels, MolecularGlutamic AcidHydroquinonesVitamin K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.