ArticleCurrent biology : CB2025
Extracellular volume expansion drives vertebrate axis elongation.
Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Coupling Vgll4b/Yap-regulated posterior cell addition with anterior vacuolation enables robust notochord elongation.Development (Cambridge, England) · 2026Article
- TiFM2.0 - versatile mechanical measurement and actuation in live embryos.Development (Cambridge, England) · 2026Article
- The role of geometry in morphogenesis.Development (Cambridge, England) · 2026Review
- Hyaluronan Underlies the Emergence of Form, Fate, and Function in Human Cardioids.bioRxiv : the preprint server for biology · 2026Article
- Adhesion differentials control the rheology of biomimetic emulsions.Biophysical journal · 2026Article
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- Article
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Ex vivo imaging reveals the spatiotemporal control of ovulation.Nature cell biology · 2024Article
- Cell density couples tissue mechanics to control the elongation speed of the body axis.iScience · 2024Article
- Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches.Development (Cambridge, England) · 2024Article
- Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores.Analytical chemistry · 2024Article
- Growth anisotropy of the extracellular matrix shapes a developing organ.Nature communications · 2023Article
- Article
- Viscoelasticity during development: What is it? and why should you care?Seminars in cell & developmental biologyReview
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13 authors.
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Abstract
The vertebrate bauplan is primarily established via the formation of embryonic tissues in a head-to-tail progression. The mechanics of this elongation, which requires the presomitic mesoderm (PSM), remain poorly understood. Here, we find that avian PSM explants can elongate autonomously when physically confined in vitro, producing a pushing force promoting posterior elongation of the embryo. This tissue elongation is caused by volumetric expansion, which results from an increase in the extracellular fraction accompanied by graded cellular motility. We show that fibroblast growth factor (FGF) signaling promotes glycolysis-dependent production of hyaluronic acid (HA), which is required for expansion of the posterior PSM. Our findings link body axis elongation to tissue expansion through the metabolic control of extracellular matrix production downstream of FGF signaling.
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