Evidence map›Paper›PMID 39879631›Full record

ArticleThe Journal of infectious diseases2025

Population-Level Impact of Human Papillomavirus Vaccination on the Incidence of Genital Warts in Sweden.

Ana Martina Astorga Alsina, Eva Herweijer, Jiayao Lei

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ana Martina Astorga AlsinaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0009-0002-3149-4325
Eva HerweijerInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3876-7453
Jiayao LeiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4718-1414

Funding

Karolinska InstitutetSwedish Cancer Society 24 3862Swedish Research Council 2023-01809Swedish Research Council for HealthWorking Life, and Welfare 2023-01221
6 · The paper itself

Abstract

backgroundSweden introduced human papillomavirus (HPV) vaccination in 2006 via opportunistic, subsidized, catch-up, and school-based programs. Notably, genital warts (GW) are the first observable clinical outcome following HPV-6/11 infection, the strains targeted by vaccination. We aim to assess the incidence of GW in Sweden and its change throughout vaccination programs.

methodsThis ecological study used Swedish registers to obtain national population data and cases of GW from 2006 to 2018 in 15- to 44-year-old men and women. We used Poisson models to estimate GW incidence change after vaccination compared to a prevaccination period, stratified by age and sex, and incidence change of GW in birth cohorts eligible for vaccination compared to a prevaccination cohort. Finally, we estimated GW cases averted in each vaccinated cohort.

resultsThe incidence of GW decreased during periods following HPV vaccination. In 2016-2018, over a decade after vaccination availability, incidence decreased by 89% (95% confidence interval [CI], 83%-93%), 73% (95% CI, 71%-75%), 50% (95% CI, 43%-56%), and 20% (95% CI, 10%-28%) in women aged 15-19, 20-24, 25-29, and 30-34 years, respectively. A similar reduction was observable in men, although of lower magnitude. We estimated 18 890 and 12 343 GW cases averted among vaccinated cohorts of women and men, respectively.

conclusionsWe report on population-level decreases of GW incidence in women and men following increased vaccination coverage. Cohorts eligible for school-based vaccination recorded the largest decrease in GW incidence in Sweden to date. For the period under study, decreases among men could be attributed to herd effects.

Indexed as

Condylomata AcuminataPapillomavirus InfectionsPapillomavirus VaccinesAdolescentAdultFemaleHuman Papillomavirus VirusesHumansIncidenceMaleRegistriesSwedenVaccinationYoung AdultPapillomavirus Vaccinescondylomaherd effecthuman papillomavirusSwedenvaccination

Identifiers

PMID39879631
PMCPMC12308650

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.