Evidence map›Paper›PMID 39879546›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Type I Interferon Targets Alveolar Macrophages to Promote Bacterial Pneumonia after Viral Infection.

Sunil Palani, Md Bashir Uddin, Michael McKelvey, Shengjun Shao, Wenzhe Wu, Xiaoyong Bao, Jiaren Sun, Keer Sun

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. (Inter)feron the Reaper: New Insights on an Old Cytokine in Secondary Bacterial Pneumonia.American journal of respiratory cell and molecular biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sunil PalaniDepartment of Microbiology and Immunology.
Md Bashir UddinDepartment of Microbiology and Immunology.
Michael McKelveyDepartment of Experimental Pathology, and.
Shengjun ShaoDepartment of Microbiology and Immunology.
Wenzhe WuDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas; and.
Xiaoyong BaoDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas; and.
Jiaren SunDepartment of Microbiology and Immunology.
Keer SunDepartment of Microbiology and Immunology.ORCID 0000-0002-9702-9584

Funding

Oxidative Burst in Influenza and MRSA Co-infectionR01HL118408 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, KEER · 2013 to 2022
$3.9M
tRNA-derived RNA Fragments and their Role in Nasal SARS-CoV-2 InfectionR21AI166543 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BAO, XIAOYONG · 2022 to 2023
$680k
GPR120 regulation of intestinal IgA responses and gut IgA-coated bacteriaR21AI150210 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2020 to 2021
$435k
NHLBI NIH HHS R01 HL118408NIAID NIH HHS R21 AI150210NIAID NIH HHS R21 AI166543
6 · The paper itself

Abstract

Exposure to influenza A virus, respiratory syncytial virus, and human metapneumovirus is well known to increase the risk of

Indexed as

Interferon Type IMacrophages, AlveolarPneumonia, BacterialAnimalsHumansInfluenza A virusMetapneumovirusMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaRespiratory Syncytial Virus InfectionsSignal TransductionStreptococcus pneumoniaeIfnar1 protein, mouseInterferon Type IReceptor, Interferon alpha-betacoinfectioninfluenzaRSVS. pneumoniae

Identifiers

PMID39879546
PMCPMC12334883

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.