Evidence map›Paper›PMID 39879412›Full record

ArticleArquivos brasileiros de oftalmologia2025

Retinopathy of prematurity: Accuracy of ROPScore and WINROP algorithms in a Brazilian population.

Amanda F L Morais, Luisa M Hopker, Nilva S B Moraes, Bernardo Reichert, Murilo V De Prá, Anna Carolina B Linhares, Ricardo M Takashima, Norma Allemann

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Article in Arquivos brasileiros de oftalmologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Amanda F L MoraisDepartment of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-7589-1624
Luisa M HopkerDepartment of Ophthalmology, Hospital de Olhos do Paraná, Curitiba, PR, Brazil.ORCID 0000-0001-6875-9820
Nilva S B MoraesDepartment of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0003-4093-6818
Bernardo ReichertMédicos de Olhos S.A., Curitiba, PR, Brazil.ORCID 0000-0002-9308-6135
Murilo V De PráMédicos de Olhos S.A., Curitiba, PR, Brazil.ORCID 0000-0002-6705-1895
Anna Carolina B LinharesUniversidade Federal do Paraná, Curitiba, PR, Brazil.ORCID 0009-0006-8482-389X
Ricardo M TakashimaUniversidade Positivo, Curitiba, PR, Brazil.
Norma AllemannDepartment of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0001-5432-4287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the sensitivity and specificity of the retinopathy of prematurity score (ROPScore) and weight, insulin-like growth factor-1, retinopathy of prematurity algorithm in predicting the risk of developing severe retinopathy of prematurity (prethreshold type 1) in a sample of preterm infants in Brazil.

methodsRetrospective analysis of medical records of preterm infants (n=288) with birth weight of ≤1500 g and/or gestational age of 23-32 weeks in a neonatal unit in Southern Brazil from May 2013 to December 2020 (92 months).

resultsThe incidence of confirmed severe retinopathy of prematurity was 6.6%. ROPScore showed a 100% sensitivity, 44.6% specificity (95% confidence interval [CI] 38.7-50.6), 11.3% positive predictive value (95% CI 6.5-16.1), and 100% negative predictive value in predicting severe retinopathy of prematurity. The weight, insulin-like growth factor-1, retinopathy of prematurity algorithm demonstrated a 78.9% sensitivity (95% CI 60.6-97.3), 51.3% specificity (95% CI 45.3-57.3), 10.3% positive predictive value (95% CI 5.3-15.2), and 97.2% negative predictive value (95% CI 94.5-99.9).

conclusionROPScore identified all patients at risk for severe retinopathy of prematurity. These findings support incorporating ROPScore into Brazilian guidelines to optimize retinopathy of prematurity screening and reduce unnecessary ophthalmologic examinations. Weight, insulin-like growth factor-1, retinopathy of prematurity's suboptimal performance in this Brazilian sample highlights the need for country-specific algorithm adjustments.

Indexed as

AlgorithmsRetinopathy of PrematurityBirth WeightBrazilFemaleGestational AgeHumansIncidenceInfant, NewbornInfant, PrematureInsulin-Like Growth Factor IMaleNeonatal ScreeningPredictive Value of TestsReproducibility of ResultsRetrospective StudiesInsulin-Like Growth Factor I

Identifiers

PMID39879412
PMCPMC12997629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.