ArticleScience advances2025
Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Time-restricted eating, immunomodulation and ketone metabolism in humans.Metabolism: clinical and experimental · 2026Review
- Acetyl-CoA-dependent processes are preferentially supported by local metabolite synthesis.Science advances · 2026Article
- Ketogenesis as a Metabolic Checkpoint in MASLD: Implications for Disease Progression and Therapy.Metabolites · 2026Review
- Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement.Molecular metabolism · 2026Article
- Age-driven marbling in Haimen goat meat: multi-omics dissection of lipid/amino signatures and IMF regulatory networks.Food chemistry: X · 2026Article
- Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis.Trends in endocrinology and metabolism: TEM · 2026Review
- Diet-Dependent Cognitive Benefits of Exogenous Ketone Body Precursor, (R,S)-1,3,-Butanediol, in a Mouse Model of Tauopathy.bioRxiv : the preprint server for biology · 2026Article
- Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.Function (Oxford, England) · 2026Article
- Plasma fatty acid composition modifies the cardiovascular risk of long-term PMLipids in health and disease · 2026Article
- Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression.Diabetes, obesity & metabolism · 2026Review
- Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis.Molecular metabolism · 2026Article
- Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement.bioRxiv : the preprint server for biology · 2026Article
- Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method.Talanta · 2026Article
- Mechanisms of energy metabolism reprogramming and homeostasis maintenance in overwintering hibernating animals.Frontiers in veterinary science · 2026Review
- Dietary sulfur amino acid restriction improves glucose homeostasis through hepaticbioRxiv : the preprint server for biology · 2025Article
- An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells.Nature metabolism · 2025Article
- Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.bioRxiv : the preprint server for biology · 2025Article
- Reversible histone deacetylase activity catalyzes lysine acylation.Nature chemical biology · 2025Article
- Ketone body supplementation in keto-adapted mice reveals metabolic adaptations and glycogen-independent exercise capacity.Physiological reports · 2025Article
- Ketone metabolites in metabolic dysfunction-associated steatotic liver disease progression: optimizing keto-therapeutic strategies.American journal of physiology. Endocrinology and metabolism · 2025Review
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Authors and funding
13 authors.
Eric D QueathemDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0009-0001-7618-9554
Zahra MoazzamiDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-9056-4795
David B StaggDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-1044-118X
Alisa B NelsonDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0001-7685-1803
Kyle FulghumDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0003-0568-3544
Abdirahman HayirDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0009-0000-4054-3323
Alisha SeayDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0009-0003-1255-7463
Jacob R GillinghamDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-6717-9960
D André d'AvignonDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Xianlin HanDepartment of Medicine-Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-8615-2413
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-3858-1272
Peter A CrawfordDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0001-8597-4426
Patrycja PuchalskaDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-1875-1203
Funding
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6MKETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2MTRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3MTraining Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6MKetogenic Oscillations and Neurometabolic HealthspanR01AG069781 · NIA · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, THYFAULT, JOHN P · 2020 to 2024
$2.3MMinnesota Postbaccalaureate Research Education Program in Diabetes, Endocrinology and Metabolic DiseasesR25DK140753 · NIDDK · UNIVERSITY OF MINNESOTA · PI Emilyn Alejandro, LISA Senye CHOW · 2024 to 2026
$1.8MInclusive Excellence Training Program in the Systems Biology of Cardiovascular InflammationT32HL166142 · NHLBI · UNIVERSITY OF MINNESOTA · PI JOSEPH Mark METZGER · 2023 to 2026
$817kNHLBI NIH HHS T32 HL144472NHLBI NIH HHS T32 HL166142NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG069781NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R25 DK140753NIDDK NIH HHS T32 DK007203
Abstract
Ketogenesis is a dynamic metabolic conduit supporting hepatic fat oxidation particularly when carbohydrates are in short supply. Ketone bodies may be recycled into anabolic substrates, but a physiological role for this process has not been identified. Here, we use mass spectrometry-based
Indexed as
Fatty Acids, UnsaturatedHomeostasisKetone BodiesLiverAnimalsHepatocytesLipid MetabolismLipidomicsLipogenesisMaleMiceFatty Acids, UnsaturatedKetone Bodies
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.