ArticleJAMA network open2025
Mental Health Disparities by Sexual Orientation and Gender Identity in the All of Us Research Program.
Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inclusion of sexual- and gender-minoritized individuals in randomized clinical trials of first-line treatments for posttraumatic stress disorder: A systematic literature review.Journal of traumatic stress · 2026Pooled it
- Loneliness and Bullying by Siblings in Gender-Diverse Adolescents: Results From the Population-Based Generation R Study.JAACAP open · 2026Article
- Women's experience with gender-based discrimination, social support, and health outcomes: A subgroup analysis of the AllAnalyses of social issues and public policy : ASAP · 2026Article
- Obsessive-Compulsive Disorder in three understudied populations: A review of Latino, Black, and Sexual & Gender Minority Individuals.Current psychiatry reports · 2026Review
- Mental health status of sexually diverse youth at age 23: Cross-sectional data from the Quebec Longitudinal Study of Child Development.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Gender, Sexuality, Mental Health, and Sexual Well-Being: Charting Burdens, Pathways, and an Affirmative Research Agenda.Healthcare (Basel, Switzerland) · 2026Article
- Optimizing Engagement with Digital Mental Health Resources Among Sexual and Gender Minority Users: Protocol for a Series of Microrandomized Trials.JMIR research protocols · 2026Article
- The Prevalence of Poor Behavioral Health Among University Students by Gender, Sexual Orientation, and Racial Identity: The Role of Discrimination and Microaggressions.International journal of environmental research and public health · 2026Article
- China's 2017 Censorship Policy and Attitudes Towards Same-Sex Behavior: An Interrupted Time Series Analysis.Archives of sexual behavior · 2026Article
- Health Disparities Between Stress-Related Mental Health Conditions and Chronic Physical Health Conditions Among Hispanic and Latinx Sexual and Gender Minority Individuals: Findings from the All of Us Research Program.Psychology of sexual orientation and gender diversity · 2026Article
- Compulsive Sexual Behaviors, Pornography Consumption, and Co-Occurring Disorders Among College Students.Archives of sexual behavior · 2026Article
- A Daily Diary Study of Discrimination and Substance Use in Transgender and Nonbinary Adults.Psychology of sexual orientation and gender diversity · 2026Article
- The multifactor chain mediation model of anxiety in the MSM population: the pathways of perceived social support, self-esteem, and psychological resilience.Scientific reports · 2026Article
- Disparities in cancer screening and preventive care access among LGBTQ+ populations: A cross-sectional study.Journal of family medicine and primary care · 2026Article
- The moderating role of HIV status in the association between gender identity and depression among sexual and gender minorities in Abuja, Nigeria.PLOS mental health · 2026Article
- Gender Differences in Trajectories of Depressive Symptoms Among Talkspace Clients: Naturalistic Observational Study.JMIR formative research · 2025Observational
- Network analysis of comorbid mental health disorders among people with HIV in the All of Us Research Program.Research square · 2025Article
- Obstacles to Obtain Care Among Sexual and Gender Minorities With Chronic Rhinosinusitis.Laryngoscope investigative otolaryngology · 2025Article
- Factors Associated with Perceived Coercion in Adults Receiving Psychiatric Care: A Scoping Review.Healthcare (Basel, Switzerland) · 2025Review
- Unveiling health disparities: Diagnostic prevalences in a transgender cohort versus matched controls.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Importance: Limited research explores mental health disparities between individuals in sexual and gender minority (SGM) populations and cisgender heterosexual (non-SGM) populations using national-level data. Objective: To explore mental health disparities between SGM and non-SGM populations across sexual orientation, sex assigned at birth, and gender identity within the All of Us Research Program. Design, Setting, and Participants: This cross-sectional study used survey data and linked electronic health records of eligible All of Us Research Program participants from May 31, 2017, to June 30, 2022. Exposure: Self-identified SGM status. Main Outcomes and Measures: Prevalence of common mental health conditions identified from linked electronic health records. Logistic regression adjusted for age, race and ethnicity, educational level, income, employment status, and geographic region was used to assess the association between SGM status and mental health conditions. Results: Among 413 457 participants, 269 947 (65.3%) were included in the analysis (median age, 59 [IQR, 43-70] years), with 22 189 (8.2%) self-identified as SGM. Men with cisgender sexual minority identity had higher odds of bipolar disorder (adjusted odds ratio [AOR], 1.87; 95% CI, 1.70-2.56) compared with cisgender heterosexual men. Women with cisgender sexual minority identity had higher odds of bipolar disorder (AOR, 2.09; 95% CI, 1.95-2.25) compared with cisgender heterosexual women. Gender diverse people assigned female sex at birth had higher odds of posttraumatic stress disorder (PTSD) compared with both cisgender heterosexual men (AOR, 3.67; 95% CI, 2.99-4.50) and cisgender heterosexual women (AOR, 2.77; 95% CI, 2.26-3.40). Gender diverse individuals assigned male sex at birth had higher odds of bipolar disorder (AOR, 2.35; 95% CI, 1.66-3.33) compared with cisgender heterosexual men and higher odds of attention-deficit/hyperactivity disorder (AOR, 2.19; 95% CI, 1.48-3.23) compared with cisgender heterosexual women. Transgender men had higher odds of depression (AOR, 2.11; 95% CI, 1.80-2.49) compared with cisgender heterosexual men, while transgender women had higher odds of any personality disorder (AOR, 2.71; 95% CI, 1.84-3.99) compared with cisgender heterosexual women. Conclusions and Relevance: In this cross-sectional study of participants in the All of Us Research Program, there were significant mental health disparities between participants in SGM and non-SGM groups. These findings underscore the need for tailored mental health interventions to improve the well-being of SGM populations, while noting that the associations do not imply causality but reflect the stigma and minority stress experienced by these individuals.
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