Evidence map›Paper›PMID 39878879›Full record

ArticleMetabolic brain disease2025

2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP

Kechen Du, Ying Su, Qiong Song, Shuai Chen, Ribao Wu, Xiahong Teng, Renbin Huang, Lihui Wang, Chunlin Zou

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kechen Du *Key Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0001-6740-7401
Ying Su *Key Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0009-0003-4663-4420
Qiong Song *Key Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0001-9828-5611
Shuai ChenKey Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0003-0745-9546
Ribao WuKey Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0002-4104-2392
Xiahong TengSchool of International Education, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0002-6740-0397
Renbin HuangPharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0001-9784-2850
Lihui WangKey Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China. wanglihui@gxmu.edu.cn.ORCID 0000-0002-7272-5823
Chunlin ZouKey Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China. zouchunlin@gxmu.edu.cn.ORCID 0000-0002-3308-5544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrhoa carambola L. Several studies have documented its beneficial effects on diabetes, Alzheimer's disease, and cancer. However, its potential neuroprotective effects on Parkinson's disease (PD) have not yet been explored. The present study aimed to investigate the protective effects and underlying mechanisms of DMDD in a cellular model of PD. In this study, SH-SY5Y cells were incubated with or without DMDD following intoxication with the parkinsonian neurotoxin 1-methyl-4-phenylpyridine (MPP

Indexed as

1-Methyl-4-phenylpyridiniumApoptosisAutophagyNeuroprotective AgentsOxidative StressCell Line, TumorCell SurvivalHumansReactive Oxygen Species1-Methyl-4-phenylpyridiniumNeuroprotective AgentsReactive Oxygen Species1-methyl-4-phenylpyridine2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dioneApoptosisAutophagySH-SY5Y

Identifiers

PMID39878879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.