Evidence map›Paper›PMID 39878815›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Ginkgolide B regulates apoptosis, oxidative stress, and mitochondrial dysfunction in MPP

Xu Ding, Dongming Tan, Zhao Wang, Hongying Yin

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xu DingSchool of Traditional Chinese Medicine, Jiangsu College of Nursing, No. 9 Keji Avenue, Huai'an City, Jiangsu Province, China.
Dongming TanSchool of Traditional Chinese Medicine, Jiangsu College of Nursing, No. 9 Keji Avenue, Huai'an City, Jiangsu Province, China.
Zhao WangSchool of Traditional Chinese Medicine, Jiangsu College of Nursing, No. 9 Keji Avenue, Huai'an City, Jiangsu Province, China.
Hongying YinHuai'an Hospital Affiliated to Yangzhou University, The Fifth People's Hospital of Huai'an), 1 Huaihe East Road, Huaiyin District, Huai'an City, Jiangsu Province, China. RedyingYin88@163.com.

Funding

2023 Guiding Project of Basic Research Plan of Huai 'an HABZ202326
6 · The paper itself

Abstract

Ginkgolide B (GB) is a bioactive constituent found in Ginkgo biloba leaves that has been long recognized as a protective agent against many neurological disorders. Our study aimed to examine the effect of GB in an in vitro Parkinson's disease (PD) model and to investigate its neuroprotective mechanism as a primary objective. SK-N-SH cells were challenged with 1-methyl-4-phenylpyridinium (MPP

Indexed as

GinkgolidesHistone DeacetylasesLactonesMitochondriaNeuroprotective AgentsOxidative Stress1-Methyl-4-phenylpyridiniumApoptosisCell Line, TumorCell SurvivalHumansJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemMembrane Potential, Mitochondrial1-Methyl-4-phenylpyridiniumginkgolide BGinkgolidesHistone DeacetylasesJNK Mitogen-Activated Protein KinasesLactonesNeuroprotective AgentsGinkgolide BHDAC4JNK pathwayMPP+ toxicityNeuronal damage

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.