Evidence map›Paper›PMID 39878791›Full record

ArticleWorld journal of microbiology & biotechnology2025

Isolation and structure determination of a new antibacterial lanthipeptide derived from the marine derived bacterium Lysinibacillus sp.CTST325.

Chanaphat Thetsana, Ryota Moriuchi, Shinya Kodani

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Article in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chanaphat ThetsanaGraduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.
Ryota MoriuchiShizuoka Instrumental Analysis Center, Shizuoka University, Shizuoka, Japan.
Shinya KodaniGraduate School of Science and Technology, Shizuoka University, Shizuoka, Japan. kodani.shinya@shizuoka.ac.jp.ORCID http://orcid.org/0000-0002-6792-1184

Funding

Institute for Fermentation, OSAKA (IFO) LA-2024-002Japan Society for the Promotion of Science 21KK0101
6 · The paper itself

Abstract

Marine resources are attractive for screening new useful bacteria. From a marine sediment sample, we performed isolation and screening of bacterial strains in search of new bioactive compounds. HPLC and ESI-MS analysis indicated that the new bacterium, Lysinibacillus sp. CTST325 (NBRC 116944), produced a new peptidic compound, lysinibacin. Genome sequence analysis of Lysinibacillus sp. CTST325 indicated the presence of several biosynthetic gene clusters for secondary metabolites, including lanthipeptides. The structure determination of lysinibacin was performed using CID-MS and NMR spectral data. As a result, lysinibacin was identified as a new class III lanthipeptide, containing N-dimethylated Tyr at the N-terminus and the unusual amino acid labionin at the C-terminus. The biosynthetic gene cluster of lysinibacin was identified from the genome data of the strain CTST325, based on the structure of lysinibacin. Lysinibacin showed antibacterial activity against Gram-positive bacteria.

Indexed as

Anti-Bacterial AgentsBacillaceaePeptidesAquatic OrganismsBiosynthetic PathwaysChromatography, High Pressure LiquidGenome, BacterialGeologic SedimentsGram-Positive BacteriaMicrobial Sensitivity TestsMultigene FamilyPhylogenyAnti-Bacterial AgentsPeptides

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.