Evidence map›Paper›PMID 39878789›Full record

ArticleMikrochimica acta2025

Molecularly imprinted hydrogels embedded with two-dimensional photonic crystals for the detection of dexamethasone/betamethasone sodium phosphate.

Suiyuan Huang, Xuehua Sun, Jianwei Xin, Panpan Ma, Yuqi Zhang, Zhongyu Cai, Ji-Jiang Wang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Suiyuan Huang *Key Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China.
Xuehua Sun *Key Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China.
Jianwei XinKey Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China.
Panpan MaKey Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China.
Yuqi ZhangKey Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China. yqzhang@yau.edu.cn.ORCID http://orcid.org/0000-0001-9577-3150
Zhongyu CaiSchool of Instrumentation and Optoelectronic Engineering, School of Space and Environment, Beihang University, Beijing, 100191, China. caizy@buaa.edu.cn.ORCID http://orcid.org/0000-0001-9251-8154
Ji-Jiang WangKey Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, School of Medicine, Yan'an University, Yan'an, Shaanxi, 716000, People's Republic of China.

Funding

National Natural Science Foundation of China 21663032National Natural Science Foundation of China 22076008Open Sharing Platform for Scientific and Technological Resources of Shaanxi Province 2021PT-004
6 · The paper itself

Abstract

Dexamethasone sodium phosphate (DSP) and betamethasone sodium phosphate (BSP) imprinted hydrogels embedded with two-dimensional photonic crystals (2DPC) were developed as hormones-sensitive photonic hydrogel sensors with highly sensitive, selective, anti-interference and reproducible recognition capability. The DSP/BSP molecularly imprinted photonic hydrogels (denoted as DSP-MIPH and BSP-MIPH) can specifically recognize DSP/BSP by rebinding the DSP/BET molecules to nanocavities in the hydrogel network. This recognition is enabled by the similar shape, size, and binding sites of the nanocavities to the target molecules. The rebinding of hormones molecules causes the hydrogel to swell, resulting in a particle spacing increase of the embedded 2DPC of the hydrogel. The particle spacing increase can be used as sensing signal and can be acquired by simply measuring the Debye diffraction diameters of the photonic hydrogel sensor before and after exposure with a laser pointer and a ruler. The particle spacing increments of the DSP-MIPH and BSP-MIPH sensors linearly change when DSP and BSP concentrations changes within the ranges 0.025-1 μM, 10-100 μM, and 100-500 μM, and the limits of detection (LoD) are 21.8 nM for DSP and 12.6 nM for BSP, respectively. These photonic hydrogel sensors were successfully applied to the determination of DSP/BSP contents in the real pharmaceutical injections, providing an ideal strategy for the development of portable hormones sensors.

Indexed as

Debye diffractionDetection of hormonesMolecularly imprinted hydrogelsParticle spacing changesTwo-dimensional photonic crystals

Identifiers

PMID39878789

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