Evidence map›Paper›PMID 39878534›Full record

ArticleFuture medicinal chemistry2025

A series of benzensulfonamide derivatives as new potent carbonic anhydrase IX and XII inhibitors.

Susanna Nencetti, Doretta Cuffaro, Lidia Ciccone, Alessio Nocentini, Miriana Di Stefano, Giulio Poli, Marco Macchia, Tiziano Tuccinardi, Elisa Nuti, Claudiu T Supuran and 2 more

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In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Susanna NencettiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-3547-7277
Doretta CuffaroDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Lidia CicconeDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Alessio NocentiniDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Sesto Fiorentino, Italy.
Miriana Di StefanoDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Giulio PoliDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Marco MacchiaDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Elisa NutiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Claudiu T SupuranDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Sesto Fiorentino, Italy.
Armando RosselloDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Elisabetta OrlandiniResearch Center "E. Piaggio" Università di, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimHuman carbonic anhydrases (hCAs) are involved in many physiological processes including respiration, pH control, ion transport, bone resorption, and gastric fluid secretion. Recently, CA IX and CA XII have been studied for their role in cancer diseases, motivating the design of inhibitors of these isoforms. MATERIAL AND

methodHere, we used the tail approach to design a new series of monoaryl ( RESULTS AND

conclusionThe best compound was

Indexed as

Antigens, NeoplasmCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesSulfonamidesHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIISulfonamidesbenzensulfonamide derivativesCarbonic anhydrase inhibitors (CAIs)Carbonic anhydrase IX, XIIenzyme inhibitionmetalloenzymes

Identifiers

PMID39878534
PMCPMC11792798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.