Evidence map›Paper›PMID 39878533›Full record

ArticlemBio2025

Two new enzymes that liberate undecaprenyl-phosphate to replenish the carrier lipid pool during envelope stress.

Ian J Roney, David Z Rudner

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ian J RoneyDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0236-7143

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI BELTZ, GERALD A · 2014 to 2018
$25.2M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Growth and differentiation in Bacillus subtilisR35GM145299 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID Z RUDNER · 2022 to 2026
$2.9M
Cell Envelope Homeostasis in Bacillus subtilisR01GM127399 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2019 to 2022
$1.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM086466HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM127399HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM145299NIAID NIH HHS U19 AI109764NIAID NIH HHS U19 AI158028NIGMS NIH HHS R01 GM086466NIGMS NIH HHS R01 GM127399NIGMS NIH HHS R35 GM145299
6 · The paper itself

Abstract

The 55-carbon isoprenoid, undecaprenyl-phosphate (UndP), is a universal carrier lipid that ferries most glycans and glycopolymers across the cytoplasmic membrane in bacteria. In addition to peptidoglycan precursors, UndP transports O-antigen, capsule, wall teichoic acids, and sugar modifications. How this shared but limited lipid is distributed among competing pathways is just beginning to be elucidated. We recently reported that in the bacterium

Indexed as

Bacillus subtilisBacterial ProteinsCell WallHemiterpenesPolyisoprenyl PhosphatesStress, PhysiologicalGene Expression Regulation, BacterialPeptidoglycanBacterial ProteinsHemiterpenesPeptidoglycanPolyisoprenyl Phosphatesundecaprenyl phosphatebacterial cell envelopeC55-PpeptidoglycanPGSigMstress-responseundecaprenyl-phosphateWTA

Identifiers

PMID39878533
PMCPMC11898649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.