Evidence map›Paper›PMID 39878494›Full record

ArticleInfection and immunity2025

Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins.

Anders F Johnson, Summer D Bushman, Doris L LaRock, Juan Manuel Díaz, John K McCormick, Christopher N LaRock

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Impact of cathelicidin cleavage by SpeB onbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Pentamidine inhibition of streptopain attenuatesbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anders F JohnsonDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Summer D BushmanDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5976-9805
Doris L LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Juan Manuel DíazDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
John K McCormickDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0003-3742-7289
Christopher N LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-3035-5331

Funding

Proteolytic regulation of the Streptococcus pyogenes cell surfaceR01AI153071 · NIAID · EMORY UNIVERSITY · PI LAROCK, CHRISTOPHER N · 2021 to 2025
$1.9M
GSDMA roles in skin innate immune defenseR01AI180089 · NIAID · EMORY UNIVERSITY · PI Christopher N LaRock · 2024 to 2026
$1.8M
Burroughs Wellcome Fund (BWF)Canadian Government | Canadian Institutes of Health Research (CIHR) 461623Fondation Leducq (Leducq Foundation)HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI153071HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI180089NIAID NIH HHS R01 AI153071NIAID NIH HHS R01 AI180089
6 · The paper itself

Abstract

Streptococcal pyogenic exotoxins (Spe proteins) secreted by

Indexed as

Bacterial ProteinsExotoxinsPeptide HydrolasesStreptococcus pyogenesSuperantigensAnimalsHumansInflammationStaphylococcus aureusStreptococcal InfectionsBacterial Proteinserythrogenic toxinExotoxinsPeptide HydrolasesSuperantigensgroup A StreptococcusproteasesStreptococcus pyogenessuperantigenstoxin-mediated diseases

Identifiers

PMID39878494
PMCPMC11895496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.