Evidence map›Paper›PMID 39878476›Full record

ArticlemBio2025

VopX, a novel

Megan Ulbrich, Christopher H Seward, Andrei I Ivanov, Brian M Ward, J Scott Butler, Michelle Dziejman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megan UlbrichDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0009-0008-3082-7056
Christopher H SewardDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Andrei I IvanovDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Brian M WardDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-6703-924X
J Scott ButlerDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Michelle DziejmanDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-3960-0703

Funding

Novel cytoskeletal mechanisms of pathogenic bacteria interactions with intestinal epitheliumR01DK131550 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Andrei Ivanovich Ivanov · 2022 to 2026
$2.5M
Novel effector protein functions encoded by T3SS positive V. choleraeR01AI126005 · NIAID · UNIVERSITY OF ROCHESTER · PI DZIEJMAN, MICHELLE · 2017 to 2021
$2.4M
Pathogenic mechanisms of non-01/non-0139 V. choleraeR01AI073785 · NIAID · UNIVERSITY OF ROCHESTER · PI DZIEJMAN, MICHELLE · 2008 to 2012
$1.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI126005, R01AI073785HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK131550NIAID NIH HHS R01 AI073785NIAID NIH HHS R01 AI126005NIDDK NIH HHS R01 DK131550
6 · The paper itself

Abstract

Pathogenic IMPORTANCE: Despite different infection strategies, enteric pathogens commonly employ a T3SS to colonize the human host and cause disease. Effector proteins are unique to each T3SS-encoding bacterial species and generally lack conserved amino acid sequences. However, T3SS effectors from diverse pathogens target and manipulate common host cell structures and signaling proteins, such as the actin cytoskeleton and MAPK pathway components. T3SS-encoding

Indexed as

ActinsBacterial ProteinsHost-Pathogen InteractionsType III Secretion SystemsVibrio choleraeVirulence FactorsCaco-2 CellsCholeraHeLa CellsHumansActinsBacterial ProteinsType III Secretion SystemsVirulence FactorscytoskeletoneffectorpathogenesisT3SSV. cholerae

Identifiers

PMID39878476
PMCPMC11898728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.