Evidence map›Paper›PMID 39878373›Full record

ReviewClinical microbiology reviews2025

Update on the evolving landscape of pneumococcal capsule types: new discoveries and way forward.

Feroze A Ganaie, Bernard W Beall, Jigui Yu, Mark van der Linden, Lesley McGee, Catherine Satzke, Sam Manna, Stephanie W Lo, Stephen D Bentley, Neil Ravenscroft and 1 more

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Regulation of PBP2x Surface Localization byPathogens (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Surveillance of invasive pneumococcal disease in Germany: surge in PCV13 serotypes and new challenges, 2017 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  13. Review
  14. Microbiology spectrum · 2026
    Article
  15. Article
  16. Digital PCR linkage analysis resolvesMicrobiology spectrum · 2026
    Article
  17. Capsule and PspA Cooperatively Confer Resistance ofInternational journal of molecular sciences · 2026
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feroze A GanaieDepartment of Medicine, Division of Pulmonary/Allergy/Critical Care, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-1250-4604
Bernard W BeallEagle Global Scientific, LLC, Contractor to Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jigui YuDepartment of Medicine, Division of Pulmonary/Allergy/Critical Care, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mark van der LindenReference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
Lesley McGeeDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Catherine SatzkeInfection, Immunity and Global Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID 0000-0003-3164-8849
Sam MannaInfection, Immunity and Global Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID 0000-0002-7694-9605
Stephanie W LoParasites and Microbes, Wellcome Sanger Institute, Cambridge, United Kingdom.ORCID 0000-0002-2182-0222
Stephen D BentleyParasites and Microbes, Wellcome Sanger Institute, Cambridge, United Kingdom.
Neil RavenscroftDepartment of Chemistry, University of Cape Town, Rondebosch, South Africa.
Moon H NahmDepartment of Medicine, Division of Pulmonary/Allergy/Critical Care, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6922-1042

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Serogroup 19 capsule maleability leading to vaccine failureR21AI178586 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAHM, MOON H. · 2023 to 2024
$408k
MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetryS10RR026478 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, CHRISTIE G. · 2010 to 2010
$250k
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR026478NIAID NIH HHS R21 AI178586Wellcome Trust
6 · The paper itself

Abstract

SUMMARY

Indexed as

Bacterial CapsulesPneumococcal InfectionsStreptococcus pneumoniaeHumansPneumococcal VaccinesPolysaccharides, BacterialSeroepidemiologic StudiesSerogroupSerotypingPneumococcal VaccinesPolysaccharides, Bacterialcapsular overlapcapsular polysaccharidecapsule typescarbohydratepneumococcal conjugate vaccinesseroepidemiologyserotypesStreptococcus pneumoniae

Identifiers

PMID39878373
PMCPMC11905375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.