Evidence map›Paper›PMID 39878295›Full record

ArticleAlzheimer disease and associated disorders

Refractory Psychosis as a Red Flag for End of Life in Individuals With Dementia With Lewy Bodies: A Case Series and Re-analysis of Prior Qualitative Data.

Melissa J Armstrong, James E Galvin, Carol Manning, Bradley F Boeve, Gregory M Pontone, Angela S Taylor, Bhavana Patel, Jori E Fleisher, Susan M Maixner

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa J ArmstrongDepartment of Neurology, University of Florida College of Medicine.ORCID 0000-0002-2163-1907
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL.
Carol ManningDepartment of Neurology, University of Virginia, Charlottesville, VA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN.
Gregory M PontoneDepartment of Neurology, University of Florida College of Medicine.
Angela S TaylorLewy Body Dementia Association, Lilburn, GA.
Bhavana PatelDepartment of Neurology, University of Florida College of Medicine.
Jori E FleisherDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Susan M MaixnerDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.

Funding

Statistics CoreU19AG078105 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Abraham Aizer Brody, JOSHUA CHODOSH · 2023 to 2026
$58.3M
Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy BodiesR01AG071643 · NIA · COGNITION THERAPEUTICS, INC. · PI CAGGIANO, ANTHONY O, GALVIN, JAMES E · 2021 to 2023
$29.5M
Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Rosie E Curiel Cid · 2020 to 2026
$25.6M
Research Methods CoreP01AG066584 · NIA · WASHINGTON STATE UNIVERSITY · PI KA'IMI ALOHILANI SINCLAIR · 2021 to 2026
$17.4M
Dementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6M
Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2021 to 2025
$13.8M
Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep ApneaR01AG054435 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GOONERATNE, NALAKA S, WOLK, DAVID A · 2017 to 2020
$10.3M
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationR01NS101483 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2019 to 2023
$8.0M
University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI GOLDE, TODD E · 2015 to 2019
$7.3M
The LUCINDA TrialR01AG057681 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ATWOOD, CRAIG S, BUTLER, TRACY A. · 2018 to 2024
$7.2M
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyR01AG056531 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEAN-LOUIS, GIRARDIN, OSORIO, RICARDO S · 2018 to 2022
$6.7M
NIA NIH HHS K23 AG073575NIA NIH HHS P01 AG066584NIA NIH HHS P30 AG059295NIA NIH HHS P30 AG066506NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG054435NIA NIH HHS R01 AG056531NIA NIH HHS R01 AG057681NIA NIH HHS R01 AG068128NIA NIH HHS R01 AG069765NIA NIH HHS R01 AG071514NIA NIH HHS R01 AG071643NIA NIH HHS R01 AG079128NIA NIH HHS R44 AG062072NIA NIH HHS R56 AG074889NIA NIH HHS RF1 AG075901NIA NIH HHS SB1 AG037357NIA NIH HHS U19 AG033655NIA NIH HHS U19 AG078105NIGMS NIH HHS S06 GM142115NIMH NIH HHS R01 MH123552NINDS NIH HHS R01 NS101483NINDS NIH HHS R01 NS121099NINDS NIH HHS U01 NS100610
6 · The paper itself

Abstract

objectivesMany individuals with dementia with Lewy bodies (DLB) die of disease-related complications, but predicting the end of life can be challenging. We identified a phenotype associated with approaching end of life.

methodsWe present 4 exemplar cases where individuals with DLB experienced refractory psychosis before death. We reviewed codebooks and quotes from 3 studies regarding end-of-life experiences in DLB to identify experiences that aligned with this phenotype.

resultsIn addition to the 4 cases, family caregivers in prior studies described prominent worsening of psychosis before death in some individuals with DLB. The worsening often occurred several months before death and was sometimes associated with rapid deterioration. Worsening psychosis was the prominent symptom and was not initially accompanied by cognitive or physical decline. In many cases, the refractory psychosis resulted in inpatient psychiatric hospitalization or residential care, but these scenarios were challenging because of the individual's behavior.

conclusionRefractory psychosis in DLB, particularly out of proportion to other symptoms, may be a signal of approaching the end of life. More research is needed to understand this phenomenon and to develop effective and safe treatments for psychosis in DLB.

Indexed as

Lewy Body DiseasePsychotic DisordersTerminal CareAgedCaregiversHumansMaleMiddle AgedQualitative Researchcase seriesdeathdementia with Lewy bodiesLewy body diseasepsychosisterminal care

Identifiers

PMID39878295
PMCPMC12109132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.