Evidence map›Paper›PMID 39878136›Full record

ArticleAutophagy2025

Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-Ting Tsai, Yi-Hsuan Cheng, Yu-Tung Lin, Chia-Ching Lin, Yi-Hua Lee, Honglei Wang, Shuhua Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shiping ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Linfang WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Shuanglong YiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yu-Ting TsaiInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Hsuan ChengInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yu-Tung LinInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chia-Ching LinInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Hua LeeInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Honglei WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Shuhua LiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Ruiqi WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yang LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Wei YanGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Chang LiuGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Kai-Wen HeInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Margaret S HoSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-2387-7564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating SNCA/α-syn (synuclein alpha) inclusions, remains elusive. Here we present evidence that aux (auxilin), the

Indexed as

alpha-SynucleinDrosophila melanogasterDrosophila ProteinsLysosomesNeurogliaVacuolar Proton-Translocating ATPasesAnimalsAutophagyDrosophilaHumansParkinson DiseasePhosphorylationProteolysisalpha-SynucleinDrosophila ProteinsVacuolar Proton-Translocating ATPasesGAK/Auxlysosomal acidificationmicrogliaparkinson diseaseSNCA/α-syn degradationV-ATPase

Identifiers

PMID39878136
PMCPMC12013444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.