Evidence map›Paper›PMID 39878110›Full record

ReviewMedicinal chemistry (Shariqah (United Arab Emirates))2026

Exploring Pyridine-Based Schemes: A Comprehensive Review on their Synthesis and Therapeutic Applications.

Amruta M Balikai, M R Pradeep Kumar, Kalirajan Rajagopal, Mohammed Ali Alshehri, Safia Obaidur Rab, Mohamed H Nafady, Talha Bin Emran

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medicinal chemistry (Shariqah (United Arab Emirates)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amruta M BalikaiDepartment of Pharmaceutical Chemistry, KLE College Pharmacy, Vidyanagar, Hubli-580031, (A Constituent unit of KAHER, Belagavi), India.
M R Pradeep KumarDepartment of Pharmaceutical Chemistry, KLE College Pharmacy, Vidyanagar, Hubli-580031, (A Constituent unit of KAHER, Belagavi), India.
Kalirajan RajagopalDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty-643001, The Nilgiris, Tamil Nadu, India.
Mohammed Ali AlshehriDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Mohamed H NafadyFaculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt.
Talha Bin EmranDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.

Funding

Deanship of Research and Graduate Studies, King Khalid University, Abha, Saudi Arabia R.G.P.2/514/45
6 · The paper itself

Abstract

Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant chemical substances with numerous applications. The application of pyridine derivatives by incorporating metals in modern medicine is growing in relevance. Due to their convenient parallelization and various testing capabilities in the chemical domain, pyridine derivatives have attracted increased interest in the treatment of various disease states. This review aims to systematically evaluate and highlight the recent advancements in the synthesis (conventional, synthetic, and green approach) and biological activities of metal-based pyridine derivatives, including antioxidant, antimicrobial, and antitumor activities, while identifying promising candidates for further drug development. By consolidating all this knowledge underlying their biological effects, this review aims to pave the way for future research endeavors and encourage the exploration of pyridine derivatives as viable therapeutic agents across a diverse array of medical applications.

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAntioxidantsPyridinesAnimalsHumansMolecular StructureAnti-Infective AgentsAntineoplastic AgentsAntioxidantspyridinePyridinesBiological effectscharacterizationdrug developmentgreen approachpyridinetherapeutic agents

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.