Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide.

Marios Zingiridis, Danae Papachristodoulou, Despoina Menegaki, Konstantinos G Froudas, Constantinos G Neochoritis

Abstract read

In one paragraph

Article in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marios ZingiridisDepartment of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.ORCID https://orcid.org/0009-0008-1150-2926

Danae PapachristodoulouDepartment of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.ORCID https://orcid.org/0009-0007-0615-4018

Despoina MenegakiDepartment of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.

Konstantinos G FroudasDepartment of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.

Constantinos G NeochoritisDepartment of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.ORCID https://orcid.org/0000-0001-5098-5504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C1 chemistry has a central role in the efficient utilization of single-carbon molecules, contributing significantly to sustainability, innovation and economic growth across various sectors. In this study, we present an efficient and rapid method for synthesizing a variety of heteroannulated pyrimidones using cyanoacetamide-based multicomponent reaction (MCR) chemistry. By utilizing specific MCR-based scaffolds as precursors and employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolopyrimidones without the need of column chromatography. Further, a single-crystal X-ray structure was obtained, revealing certain geometrical features.

Indexed as

2-amino-substituted heterocyclescyanoacetamideGewald reactionmulticomponent reaction (MCR)pyrimidine

Identifiers

PMID39877861

DOI10.3762/bjoc.21.13

PMCPMC11773184

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.