Evidence map›Paper›PMID 39877830›Full record

ArticleInternational journal of biopharmaceutical sciences2024

Alaska's Flora as a Treatment for Cancer.

Vasiliki Papakotsi, Ashley M Murphy, Madeline L Vagts, Emma J Arsenault, Colin M McGill, Brian M Barth

Abstract read
In one paragraph

Article in International journal of biopharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vasiliki PapakotsiDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824.
Ashley M MurphyDepartment of Natural Sciences, University of Alaska Southeast, Juneau AK 99801.
Madeline L VagtsDepartment of Chemistry, Biology and Health Sciences, South Dakota School of Mines and Technology, Rapid City SD 57701.
Emma J ArsenaultDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824.
Colin M McGillChemistry Department, University of Alaska Anchorage, Anchorage AK 99508.
Brian M BarthDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824.ORCID 0000-0002-3542-1804

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI DON Michael WOJCHOWSKI · 2017 to 2026
$22.8M
Tissue Repository and Animal Models CoreP01CA171983 · NCI · UNIVERSITY OF VIRGINIA · PI CLAXTON, DAVID F · 2013 to 2024
$19.9M
Regulation of Ceramide-Based Therapeutics in Acute Myeloid LeukemiaK22CA190674 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2016 to 2018
$485k
Combinatorial Decitabine and Liposomal Ceramide for Acute Myeloid LeukemiaR03CA252825 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2020 to 2020
$151k
NCI NIH HHS K22 CA190674NCI NIH HHS P01 CA171983NCI NIH HHS R03 CA252825NIGMS NIH HHS P20 GM103395NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Cancer is an extraordinarily complex illness, with many tumors ultimately developing resistance to the currently available therapeutics. This highlights a need for the discovery of new anticancer medicines. Natural products have been utilized for centuries by the indigenous people of Alaska for both spiritual and medicinal purposes and have traditionally been administered as medicine for a wide range of ailments from the common cold to cancer. These plants, including Devil's club, Labrador tea, Western skunk cabbage, and various species of wild berries such as blueberries, lingonberries, salmonberries, and high-bush cranberries, contain a wide variety of natural compounds with therapeutic potential. Various anthocyanins and polyphenols, including quercetin, as well as the pentacyclic triterpenoid ursolic acid, have been identified in these medicinal plants and have demonstrated antioxidant, anti-inflammatory, and anticancer activity. These ethnobotanicals and the unique compounds found within may be integral to the development of novel therapeutics for the treatment of cancer and other conditions.

Indexed as

Alaskaanthocyaninsanticancermedicinal plantsquercetinursolic acid

Identifiers

PMID39877830
PMCPMC11774448

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.