Effects of Inlet Geometry on Perfusion and Ischemia in Anomalous Aortic Origin of the Right Coronary Artery (AAORCA).

Anomalous aortic origin of a coronary artery (AAOCA) comprises a set of rare congenital abnormalities in the origin or path of the coronary arteries with highly variable clinical implications. This is a pilot feasibility study where we investigated the influence of the anomalous coronary artery inlet architecture on coronary perfusion using coronary blood flow computational simulations to help predict the risk for coronary ischemia in patients with anomalous aortic origin of the right coronary artery (AAORCA) with these types of anomalous coronary artery inlet architectures. We developed a protocol for generating 3D models of patient coronary artery anatomies from an IRB-approved dataset of cardiac CT images of patients with AAORCA at our institution. Coronary blood flow simulations and analysis were performed. Instantaneous flow reserve (iFR), a parameter used clinically in coronary CT analysis to determine risk for ischemia, was compared between models as a measure of ischemia. Comparing the median iFR of the coronary outlets between the four inlet variants and baseline architecture showed important differences. We observed a possible association between the proportion of the semi-minor axis and the semi-major axis of the elliptical AAORCA inlet and iFR. These observations suggest that the elliptical axis quotient may be a significant risk factor for evaluation of AAORCA severity.