Evidence map›Paper›PMID 39877647›Full record

ArticleTransplantation direct2024

Epidemiology of Epstein-Barr Virus Chronic High Viral Load in Kidney Transplant Recipients.

Christie Rampersad, Chris Wiebe, Robert Balshaw, Jared Bullard, Armelle Perez Cortes Villalobos, Aaron Trachtenberg, James Shaw, Martin Karpinski, Aviva Goldberg, Patricia Birk and 4 more

Abstract read
In one paragraph

Article in Transplantation direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christie RampersadTransplant Nephrology and Ajmera Transplant Center, University Health Network, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-8040-7908
Chris WiebeDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Robert BalshawGeorge and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada.
Jared BullardCadham Provincial Laboratory, Shared Health Manitoba, Winnipeg, MB, Canada.
Armelle Perez Cortes VillalobosDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Aaron TrachtenbergDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
James ShawDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Martin KarpinskiDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Aviva GoldbergDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Patricia BirkDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Maury PinskDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
David N RushDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Peter W NickersonDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Julie HoDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epstein-Barr virus (EBV) chronic high viral load (CHVL) may be defined by >16 000 copies/mL whole blood or >200 copies/10 Methods: This single-center observational study evaluated adult and pediatric kidney transplant recipients transplanted between 2010 and 2021 on tacrolimus/mycophenolate-based/prednisone immunosuppression. The primary outcome was EBV CHVL prevalence. Secondary outcomes included recipient characteristics, DNAemia kinetics, and posttransplant lymphoproliferative disorder (PTLD) in recipients with EBV CHVL versus low-grade DNAemia or no DNAemia. Results: Five hundred forty-one recipients had a mean follow-up of 4.6 y. Fourteen recipients (2.6%) developed EBV CHVL, 70 (12.9%) had low-grade EBV DNAemia, and 457 (84.5%) had no EBV DNAemia. EBV CHVL was more common in recipients who were Caucasian ( Conclusions: CHVL was uncommon and appeared to occur after primary EBV infection. Future studies should explore other potentially modifiable risk factors for PTLD, including optimal management of EBV DNAemia.

Identifiers

PMID39877647
PMCPMC11774561

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.