Evidence map›Paper›PMID 39877451›Full record

ArticleDiabetology international2025

Analysis of thyroid autoantibodies and the risk of insulin depletion after the clinical onset of acute-onset type 1 diabetes in Japanese patients: the TIDE-J study.

Tomoko Ebisuno, Megumi Tachibana, Akihisa Imagawa, Norio Kanatsuna, Jungo Terasaki, Norio Abiru, Takuya Awata, Hiroshi Ikegami, Yoichi Oikawa, Haruhiko Osawa and 14 more

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Article in Diabetology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tomoko EbisunoDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686 Japan.ORCID 0000-0003-2522-9752
Megumi TachibanaDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686 Japan.
Akihisa ImagawaDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686 Japan.
Norio KanatsunaDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686 Japan.
Jungo TerasakiDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686 Japan.
Norio AbiruDepartment of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Takuya AwataDepartment of Pancreatic Islet Cell Transplantation, National Center for Global Health and Medicine, Tokyo, Japan.
Hiroshi IkegamiDepartment of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan.
Yoichi OikawaDepartment of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.
Haruhiko OsawaDepartment of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.
Takeshi KatsukiDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Eiji KawasakiDiabetes Center, Shin-Koga Hospital, Kurume, Japan.
Junji KozawaDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Tetsuro KobayashiOkinaka Memorial Institute for Medical Research, Tokyo, Japan.
Akira ShimadaDepartment of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.
Kazuma TakahashiIwate Prefectural University, Takizawa, Japan.
Daisuke ChujoCenter for Clinical Research, Toyama University Hospital, Toyama, Japan.
Kyoichiro TsuchiyaDepartment of Diabetes and Endocrinology, University of Yamanashi Hospital, Yamanashi, Japan.
Kan NagasawaDivision of Diabetes, Metabolism, and Endocrine Medicine Field, Iwate Medical University, Shiwa, Japan.
Tomoyasu FukuiDivision of Diabetes and Endocrinology, Showa University School of Medicine, Tokyo, Japan.
Kazuki YasudaDepartment of Diabetes, Endocrinology, and Metabolism, Kyorin University, Mitaka, Japan.
Hisafumi YasudaDivision of Health Sciences, Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Hiroshi KajioDepartment of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Tokyo, Japan.
Toshiaki HanafusaSakai City Medical Center, Sakai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Type 1 diabetes is often accompanied by autoimmune thyroid disease. We aimed to investigate the clinical characteristics of Japanese patients with acute-onset type 1 diabetes and thyroid autoantibodies, focusing on decreased endogenous insulin secretion. Materials and methods: We examined 80 patients with acute-onset type 1 diabetes, classifying them into two groups with and without thyroid autoantibodies and compared the clinical characteristics of the two groups. A fasting serum C-peptide immunoreactivity (CPR) of less than 0.1 ng/mL was defined as insulin depletion. Results: In patients with thyroid autoantibodies, the median fasting serum CPR levels at the fourth year after the onset of type 1 diabetes were significantly lower than in those without thyroid autoantibodies ( Conclusions: Our study showed that Japanese patients with acute-onset type 1 diabetes and positive for thyroid autoantibodies had a higher risk of insulin deficiency within 5 years after the onset than those without thyroid autoantibodies.

Indexed as

Insulin secretionIslet autoantibodiesThyroid autoantibodiesType 1 diabetes mellitus

Identifiers

PMID39877451
PMCPMC11769878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.