Evidence map›Paper›PMID 39877346›Full record

ArticleFrontiers in immunology2024

Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis.

Bong-Ki Hong, Sungyong You, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Wan-Uk Kim, Ho-Youn Kim

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bong-Ki Hong *Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Republic of Korea.
Sungyong You *Urology and Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Jung Gon Kim *Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Republic of Korea.
Minhyung KimUrology and Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Naeun LeeCenter for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Republic of Korea.
Kijun LeeCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
In-Pyo BaekYiPSCELL, Inc., Seoul, Republic of Korea.
Ji Hyeon JuCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Wan-Uk KimCenter for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Republic of Korea.
Ho-Youn KimThe Catholic University of Korea and Ho-Youn Kim's Clinic for Arthritis Rheumatism, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Our aim was to investigate the insufficiently understood differences in the immune system between anti-citrullinated peptide antibody (ACPA)-positive (ACPA Methods: We performed multiple cytokine assays using sera from drug-naïve ACPA Results: Serum concentrations of interferon-γ (IFN-γ) and interleukin (IL)-12 were higher in ACPA Discussion: Compared to ACPA

Indexed as

Anti-Citrullinated Protein AntibodiesArthritis, RheumatoidInterferon-gammaMonocytesT-LymphocytesTranscriptomeAdultAgedAutoantibodiesFemaleGene Expression ProfilingHumansMaleMiddle AgedSingle-Cell AnalysisUp-RegulationAnti-Citrullinated Protein AntibodiesAutoantibodiesInterferon-gammaanti-citrullinated peptide antibodyIFITM2/3interferon signatureperipheral blood mononuclear cellsrheumatoid arthritisrheumatoid arthritis pathogenesissingle-cell transcriptomicsTh1 immunity

Identifiers

PMID39877346
PMCPMC11772891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.