Evidence map›Paper›PMID 39877299›Full record

ArticleClinical and translational radiation oncology2025

Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells.

Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M C Brown, Jeroen Essers

Abstract read
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In one paragraph

Article in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tim HeemskerkDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Celebrity GroenendijkDepartment of Radiation Science and Technology, Delft University of Technology, Delft, the Netherlands.
Marta RovitusoResearch & Development, HollandPTC, Delft, the Netherlands.
Ernst van der WalResearch & Development, HollandPTC, Delft, the Netherlands.
Wouter van BurikResearch & Development, HollandPTC, Delft, the Netherlands.
Konstantinos ChatzipapasUniversity of Brest, INSERM, LaTIM, UMR1101, F-29200 Brest, France.
Danny LathouwersDepartment of Radiation Science and Technology, Delft University of Technology, Delft, the Netherlands.
Roland KanaarDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jeremy M C BrownOptical Sciences Centre, Department of Physics and Astronomy, Swinburne University of Technology, Hawthorn, Australia.
Jeroen EssersDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Understanding the cellular and molecular effect of proton radiation, particularly the increased DNA damage complexity at the distal end of the Bragg curve, is current topic of investigation. This work aims to study Materials and methods: Proton irradiations are performed at the HollandPTC R&D proton beamline, using a double passively scattered setup. A custom water phantom setup is employed to accurately position the samples within the Bragg curve. FaDu cells are irradiated at the proximal 36 % point of the Bragg peak, (P36), proximal 80 % point of the Bragg peak (P80) and distal 20 % point of the Bragg peak (D20), with dose-averaged mean lineal energies ( Results: Clonogenic survival correlates strongly with Conclusions: This combined approach provides valuable insights into the cellular and molecular effect of proton radiation, emphasizing the increased DNA damage complexity at the distal end of the Bragg curve, and has the potential to enhance the efficacy of proton therapy.

Indexed as

Cell survivalDNA Breaks, Double-strandedDNA damageDNA repairLinear energy transferProton therapyRadiobiologySquamous cell carcinoma of head and neckTumor Suppressor p53-Binding Protein 1

Identifiers

PMID39877299
PMCPMC11772976

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.