Evidence map›Paper›PMID 39877074›Full record

ReviewInternational journal of cardiology. Cardiovascular risk and prevention2025

Comparison of percutaneous coronary intervention vs coronary artery bypass graft for left main coronary artery disease in patients with prior cerebrovascular disease: A systematic review, meta-analysis and meta-regression.

Muhammad Hamza Shuja, Firzah Shakil, Syed Hassaan Ali, Qazi Shurjeel Uddin, Ayesha Noman, Javed Iqbal, Muhammad Ahmed, Faiza Sajid, Haya Waseem Ansari, Syed Ahmed Farhan and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Muhammad Hamza ShujaDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Firzah ShakilDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Syed Hassaan AliDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Qazi Shurjeel UddinDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Ayesha NomanDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Javed IqbalNursing Department Communicable Diseases Centre Hamad Medical Corporation, Doha, Qatar.
Muhammad AhmedDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Faiza SajidDepartment of Medicine, Liaquat National Hospital and Medical College, Pakistan.
Haya Waseem AnsariDepartment of Medicine, Liaquat National Hospital and Medical College, Pakistan.
Syed Ahmed FarhanDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Huzaifa Ul Haq AnsariDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Syed Husain FarhanDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Muhammad Moiz NasirDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Sana QaziDepartment of Internal Medicine, Dow University of Health Sciences, Pakistan.
Muhammad MajidDepartment of Internal Medicine, AdventHealth Sebring, Sebring, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies suggest similar cardiovascular (CV) benefits for either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) in patients with left main coronary artery disease (LMCAD). However, limited data exist on the influence of prior cerebrovascular disease (CEVD). Thus, we aim to compare the CV outcomes in patients with LMCAD and prior CEVD, undergoing either PCI or CABG. Methods: A comprehensive search from (January 2000 to August 2024) identified three relevant studies. Outcomes analyzed included all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE), myocardial infarction (MI), and risk of stroke in patients undergoing either PCI or CABG for LMCAD. Data analysis employed a random effects model and presented hazard ratios (HR) along with their 95 % confidence intervals (CI). Results: Three studies involving 760 patients (361 PCI, 399 CABG) were included. PCI was associated with a significantly higher risk of MACCE (HR = 2.56; 95 % CI = 1.23-5.37; p = 0.01; I Conclusion: PCI significantly elevates the risk of MACCE and MI in patients with LMCAD and prior CEVD compared to CABG. However, risks of all-cause mortality, repeat stroke, and revascularization were non-significant. Comorbidities may drive the elevated risk, underscoring the need for tailored strategies in this population.

Indexed as

Cerebrovascular diseaseCoronary artery bypass graftLeft main coronary artery diseasePercutaneous coronary intervention

Identifiers

PMID39877074
PMCPMC11772956

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.