ArticleFrontiers in psychiatry2024
Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adjunctive transcranial direct current stimulation for cognitive improvement in schizophrenia: insights from a systematic review and exploratory meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Training-induced cognitive coupling emerges under sham but not active transcranial electrical stimulation in older adults: a triple-blind, randomized, sham-controlled study.Journal of neuroengineering and rehabilitation · 2026Trial
- Combining transcranial electrical stimulation with training in older adults: Effects on dual-task ability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Task-Specific Personalized Theta tACS Modulates Theta Dynamics in Associative Memory.Brain and behavior · 2026Trial
- Optimizing tACS for working memory: differential outcomes in healthy aging and non-amnestic mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- The Effects of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) on Dual-Task Performance and Upper-Limb Multi-Joint Motor Control.Life (Basel, Switzerland) · 2026Article
- Neural tracking at theta predicts drumming-induced altered states of consciousness.Scientific reports · 2026Article
- Transcranial alternating current stimulation over left DLPFC modulates feedback processing: a simultaneous tACS-fMRI study.Translational psychiatry · 2026Article
- Haemodynamic correlates of bilateral 6 Hz transcranial alternating current stimulation during working memory enhancement revealed by fNIRS.Frontiers in neuroscience · 2026Article
- Effect of theta-transcranial alternating current stimulation on working memory performance among healthy adults: A systematic review and meta-analysis.World journal of psychiatry · 2025Article
- Intrinsic calcium resonance and its modulation: insights from computational modeling.Frontiers in computational neuroscience · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance in working memory (WM) tasks. Method: In two sessions, 28 healthy participants received 5 Hz tACS or sham stimulation over the left dorsolateral prefrontal cortex (DLPFC) while performing tasks with high and low WM loads. Resting-state EEG was recorded before and after stimulations for 5 minutes. EEG power was measured at electrodes surrounding the stimulation site. Results: The results showed that tACS significantly improved reaction time (RT) compared to sham stimulation. This effect was task-specific, as tACS improved RT for hit responses only in high WM load trials, with no impact on low-load trials. Moreover, tACS significantly increased EEG power at 5 Hz and in the theta band compared to pre-stimulation levels. Discussion: These findings demonstrate that tACS applied over left DLPFC modulates post-stimulation brain oscillations at the stimulation sites - known as tACS after-effects. Furthermore, the results suggest that 5 Hz tACS enhances response speed by elevating task-related activity in the prefrontal cortex to an optimal level for task performance. Conclusion: In summary, the findings highlight the potential of tACS as a technique for modulating specific brain oscillations, with implications for research and therapeutic interventions.
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