ReviewFrontiers in psychiatry2024
Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.
Review in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Boredom in Psychiatric Disorders: Another Dimensional Construct?Brain and behavior · 2026Review
- Neurophysiological and Behavioral Responses to Gambling Cues in Individuals with Internet Gambling Disorder: A VR-EEG-GSR Study.Brain sciences · 2026Article
- Association between aperiodic activity and impulsivity in individuals with methamphetamine use disorder.Psychopharmacology · 2026Article
- MAC/MAB-RCS: An Integrative Regulatory Control Framework for Risk Stratification and Personalized Intervention in Addiction Psychiatry.Brain sciences · 2026Review
- Sex-dominant differences in resting-state EEG microstates among young adults at risk of smartphone addiction.Frontiers in human neuroscience · 2026Article
- Multisystem regulation of reward and addiction: beyond the dopaminergic system.Frontiers in pharmacology · 2026Review
- From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Frontiers in cell and developmental biology · 2026Review
- The virtue of temperance: a neurobiological perspective.Frontiers in human neuroscience · 2026Article
- Behavioural, Neural and Molecular Effects Underlying Caffeine's Addictive Properties.Addiction biology · 2025Article
- Serum Cocaine- and Amphetamine-Regulated Transcript Levels and Cooperativeness in Adolescents With Internet Gaming Disorder.Psychiatry investigation · 2025Article
- Analysis of the correlation between anthropometric indices and levels of selected hormones in relation to problematic internet use: blood parameters in problematic internet use.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral addictive disorders (BADs) have become a significant societal challenge over time. The central feature of BADs is the loss of control over engaging in and continuing behaviors, even when facing negative consequences. The neurobiological underpinnings of BADs primarily involve impairments in the reward circuitry, encompassing the ventral tegmental area, nucleus accumbens in the ventral striatum, and prefrontal cortex. These brain regions form networks that communicate through neurotransmitter signaling, leading to neurobiological changes in individuals with behavioral addictions. While dopamine has long been associated with the reward process, recent research highlights the role of other key neurotransmitters like serotonin, glutamate, and endorphins in BADs' development. These neurotransmitters interact within the reward circuitry, creating potential targets for therapeutic intervention. This improved understanding of neurotransmitter systems provides a foundation for developing targeted treatments and helps clinicians select personalized therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.